{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T11:16:39Z","timestamp":1769685399324,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007250","name":"Mississippi State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007135","name":"University of Tennessee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007135","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Photonics\/light localization techniques are essential in understanding the structural changes in biological cells\/tissues at the nano\u2010 to sub\u2010micron scale. It is now known that structural alterations begin at the nanoscale, marking the onset of cancer progression. This photonics study examines the molecular\u2010specific nano\u2010structural alterations of chronic alcoholism and probiotic effects on colon cancer using a mouse model of colon cancer. We assessed alcohol\u2010treated and azoxymethane (AOM) with dextran sulfate sodium (DSS)\u2010induced colitis models, including ethanol (EtOH) and probiotic (\n                    <jats:italic>L.casei<\/jats:italic>\n                    ) treatments separately and together. The confocal images were analyzed using the mesoscopic physics\u2010based Inverse Participation Ratio (IPR) technique to quantify structural alterations at nano\u2010 to submicron scales. Significant enhancement of cancer progression was observed in the EtOH\u2010treated group, and probiotic treatment with EtOH showed substantial reversal of these changes in colon cancer, underscoring the potential of the IPR technique in detecting and monitoring cancer progression.\n                  <\/jats:p>","DOI":"10.1002\/jbio.202500221","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:16:03Z","timestamp":1756383363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photonics Detection of Molecular\u2010Specific Spatial Structural Alterations of Cells due to Chronic Alcoholism and Probiotics Treatments in Colon Cancer"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9791-8898","authenticated-orcid":false,"given":"Ishmael","family":"Apachigawo","sequence":"first","affiliation":[{"name":"Department of Physics and Astronomy Mississippi State University  Mississippi State Mississippi USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2515-9766","authenticated-orcid":false,"given":"Pradeep K.","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhruvil","family":"Solanki","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy Mississippi State University  Mississippi State Mississippi USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santanu","family":"Maity","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy Mississippi State University  Mississippi State Mississippi USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radhakrishna","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Tennessee Health Science Center  Memphis Tennessee USA"},{"name":"Lt. 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