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Surface\u2010enhanced Raman scattering (SERS) has high sensitivity and specificity, as well as low sample consumption, but its ability to identify changes in serum compounds post\u2010ABZ treatment is unclear. This study used SERS to characterize the Raman profiles of serum from 7 normal, 9 CE\u2010model, and 10 ABZ\u2010treated mice, analyzing profile differences. Tentative peak assignments revealed ABZ\u2010induced biomolecular changes in protein structure (1000\u2009cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), uric acid (1130\u2009cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), amide III (1203\u2009cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), phospholipids, and amide I (1656\u2009cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). The top 10 principal components (PCs) accounted for 90% of the variance (PC1: 48.9%). Principal components analysis (PCA) loadings suggested these substances as markers of ABZ treatment. The results show that SERS combined with PCA is a rapid and effective method to observe serum changes in\n                    <jats:italic>Echinococcus granulosus<\/jats:italic>\n                    \u2010infected subjects.\n                  <\/jats:p>","DOI":"10.1002\/jbio.202500373","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T04:15:46Z","timestamp":1761797746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alterations of Raman Profiles of Cystic Echinococcosis Serum After Treated With\n                    <scp>ABZ<\/scp>\n                    by\n                    <scp>SERS<\/scp>"],"prefix":"10.1002","volume":"19","author":[{"given":"Ziyi","family":"Fang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention, and Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute The First Affiliated 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