{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T09:07:14Z","timestamp":1779268034982,"version":"3.51.4"},"reference-count":69,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Riboflavin\/UV\u2010A corneal collagen cross\u2010linking (CXL) is a standard treatment for early\u2010stage keratoconus. However, quantitative CXL outcomes remain limited. This study evaluated CXL effects on outflow facility and corneal biomechanics at intraocular pressures (IOPs) in ex\u00a0vivo porcine eyes. Ocular rigidity and outflow facility were derived from pressure\u2013volume and IOP decay curves using a direct manometric technique, while corneal elasticity (Young's modulus) was measured via non\u2010contact air\u2010pulse optical coherence elastography. CXL increased ocular rigidity (0.0066\u2009\u00b1\u20090.0001\u2009\u03bcL\n                    <jats:sup>\u22121<\/jats:sup>\n                    vs. 0.0060\u2009\u00b1\u20090.0002\u2009\u03bcL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and reduced outflow facility from 0.5429\u2009\u00b1\u20090.0320 to 0.1485\u2009\u00b1\u20090.0153\u2009\u03bcL\/min\/mmHg (20\u201340\u2009mmHg), compared to 0.7327\u2009\u00b1\u20090.0894\u20130.2210\u2009\u00b1\u20090.0502\u2009\u03bcL\/min\/mmHg in untreated eyes. Young's modulus increased by 92%, 89%, and 155% at 20, 30, and 40\u2009mmHg. These findings enhance our understanding of flow dynamics at IOP levels, suggesting that outflow facility and corneal biomechanics may serve as potential indicators for evaluating the effectiveness of CXL.\n                  <\/jats:p>","DOI":"10.1002\/jbio.202500432","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T22:51:28Z","timestamp":1761778288000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessing Effects of Riboflavin\/\n                    <scp>UV<\/scp>\n                    \u2010A Cross\u2010Linking on Aqueous Outflow Facility, Corneal Biomechanics and Their Association With Intraocular Pressure"],"prefix":"10.1002","volume":"19","author":[{"given":"Yilong","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Physics, Engineering and Technology University of York York UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengshuyi","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Physics, Engineering and Technology University of York York UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingyu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Centre for Medical Engineering and Technology, School of Science and Engineering University of Dundee Dundee UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Scott","sequence":"additional","affiliation":[{"name":"Th\u00e9a Pharmaceuticals Ltd Keele UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Bioengineering Keele University Stoke\u2010on\u2010Trent UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2186-5137","authenticated-orcid":false,"given":"Chunhui","family":"Li","sequence":"additional","affiliation":[{"name":"Centre for Medical Engineering and Technology, School of Science and Engineering University of Dundee Dundee UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihong","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Physics, Engineering and Technology University of York York UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2021.101559"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-19144"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0299739"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700652"},{"issue":"2","key":"e_1_2_9_6_1","first-page":"407","article-title":"Corneal Collagen Crosslinking in Keratoconus and Other Eye Disease","volume":"8","author":"Alhayek A.","year":"2015","journal-title":"International Journal of Ophthalmology"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.169813"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.optom.2014.05.006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4137\/OED.S38364"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20181012-02"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2021.07.06"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.663494"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30505"},{"issue":"6","key":"e_1_2_9_14_1","first-page":"540","article-title":"Review of Centrifugal Liquid\u2010Liquid Chromatography Using Aqueous Two\u2010Phase Solvent (ATPS) Systems: Its Scale\u2010Up and Prospects for the Future Production of High\u2010Value Biologics","volume":"10","author":"Sutherland I. 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