{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T01:45:55Z","timestamp":1774921555234,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Accurate differentiation between intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) remains challenging due to overlapping imaging features. We propose a hyperspectral imaging (HSI)\u2013based diagnostic framework using a lightweight Spectral\u2010MLP network for label\u2010free tumor classification. Seventy\u2010nine liver specimens were analyzed after spectral calibration, noise\u2010band removal, and normalization within 450\u2013900\u2009nm. Spectral analysis revealed distinct differences in hemoglobin\u2010related bands (540\u2013580\u2009nm) and lipid\/water absorption regions (760\u2013850\u2009nm), corresponding to vascular and stromal variations between ICC and HCC. The proposed Spectral\u2010MLP achieved 93.6% accuracy, 93.1% sensitivity, 94.0% specificity, and an AUC of 0.965, comparable to deeper models but with higher efficiency. These findings demonstrate that hyperspectral data combined with a simple neural network can effectively distinguish ICC from HCC and suggest that the lightweight Spectral\u2010MLP framework has the potential to provide interpretable, real\u2010time, and clinically deployable decision support for optical pathological diagnosis.<\/jats:p>","DOI":"10.1002\/jbio.202500545","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T04:44:32Z","timestamp":1764564272000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lightweight Spectral\u2010\n                    <scp>MLP<\/scp>\n                    for Hyperspectral Differentiation of Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1604-3458","authenticated-orcid":false,"given":"Qingyuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Ultrasound Tengzhou Central People's Hospital  Tengzhou China"},{"name":"Department of Medical Ultrasound, The First Affiliated Hospital of Shandong First Medical University &amp; Shandong Provincial Qianfoshan Hospital Shandong Medicine and Health Key Laboratory of Abdominal Medical Imaging  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Tengzhou Central People's Hospital  Tengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Pian","sequence":"additional","affiliation":[{"name":"Department of Neurology Tengzhou Central People's Hospital  Tengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qichao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology Tengzhou Central People's Hospital  Tengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound, The First Affiliated Hospital of Shandong First Medical University &amp; Shandong Provincial Qianfoshan Hospital Shandong Medicine and Health Key Laboratory of Abdominal Medical Imaging  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117343"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21759"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40644-023-00576-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.221429"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11112066"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13206-021-00041-0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0240444"},{"issue":"10","key":"e_1_2_9_9_1","article-title":"Advancements in Hyperspectral Imaging and Computer\u2010Aided Diagnostic Methods for the Enhanced Detection and Diagnosis of Head and Neck Cancer","volume":"12","author":"Wu I.\u2010C.","year":"2024","journal-title":"Biomedicine"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1364\/OPTICA.478211"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-89010-0_4"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-022-00184-w"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.infrared.2022.104143"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knosys.2022.110133"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.48161\/qaj.v1n2a50"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/math11030562"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aiig.2022.10.002"},{"key":"e_1_2_9_18_1","unstructured":"K. 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