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The process and mechanism of aging have long been widely concerned, but long\u2010term in\u00a0vivo evaluations of the visual nervous system have not been previously reported. In this study, naturally aging mouse models were used for long\u2010term serial evaluation, and the changes in structure and blood flow of the retina and cerebral cortex were systematically analyzed. Optical Coherence Tomography (OCT) and Optical Coherence Tomography Angiography (OCTA) were performed on mice at 3, 6, 9, and 12\u2009months of age, respectively. Structural and vascular changes with age were quantitatively evaluated. Results show that the reduction of structural thickness and vascular density of the retinal and cerebral cortex is observed. A significant correlation is also found between structural and vascular changes in the retina and cerebral cortex, indicating a consistent impact of aging on the visual nervous system.<\/jats:p>","DOI":"10.1002\/jbio.70009","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T02:31:38Z","timestamp":1742351498000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Variation of Structures and Blood Vessels of Visual Nervous System With Age"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7492-633X","authenticated-orcid":false,"given":"Ni","family":"He","sequence":"first","affiliation":[{"name":"Shanghai Institute of Technology College of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenrui","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Biomedical Engineering  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Technology College of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Technology College of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Biomedical Engineering  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuixia","family":"Dai","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Technology College of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.039"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2233"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-018-0059-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000238"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2007.00415.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4030"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2015.1004"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(02)00107-X"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.10.002"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.227"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2976\/1.2889618"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.4.564"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1120672118766807"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4266"},{"key":"e_1_2_9_16_1","first-page":"466","article-title":"Structure, Function, and Pathology of Bruch's Membrane","volume":"11","author":"Curcio C. 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