{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:43:38Z","timestamp":1780584218452,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Fourier transform infrared spectroscopy (FTIR) was used to investigate chemical differences in prostate tissue caused by prostate cancer and to correlate these data with medical. In FTIR spectra of prostate tissues, a higher amount of peaks originating from phospholipids, amide, and lipid vibrations was detected in comparison with FTIR spectra of control prostate tissues. Principal Component Analysis (PCA) showed that it is possible to differentiate two types of tissues using FTIR range corresponding to (i) phospholipids and amides and (ii) lipids. Machine learning methods showed that values of area under the curve (AUC), accuracy, F1, precision, and recall were higher for the fingerprint range than for the second one. However, values of all these parameters in both analyzed ranges were higher than 0.95. Moreover, the proposed FTIR marker of prostate cancer (wavenumber at 1685\u2009cm<jats:sup>\u22121<\/jats:sup>) correlated with bGleason, pGleason, and ISUP, which suggested that FTIR spectroscopy reflected the medical characterization of prostate cancer.<\/jats:p>","DOI":"10.1002\/jbio.70046","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T18:45:02Z","timestamp":1745261102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>FTIR<\/scp> Markers of Prostate Cancer Tissue and Their Correlation With Medical Parameters of\u00a0Tumor Aggressiveness"],"prefix":"10.1002","volume":"18","author":[{"given":"Przemys\u0142aw","family":"Mitura","sequence":"first","affiliation":[{"name":"Department of Urology and Oncological Urology Medical University of Lublin  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wies\u0142aw","family":"Paja","sequence":"additional","affiliation":[{"name":"Department of Artificial Intelligence, Institute of Computer Science University of Rzeszow  Rzesz\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartosz","family":"Klebowski","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Physics Polish Academy of Sciences  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lech","family":"Wronecki","sequence":"additional","affiliation":[{"name":"Chair and Department of Clinical Pathomorphology Medical University of Lublin  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Godzisz","sequence":"additional","affiliation":[{"name":"Department of Urology and Oncological Urology Medical University of Lublin  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Sudo\u0142","sequence":"additional","affiliation":[{"name":"Department of Urology and Oncological Urology Medical University of Lublin  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Bar","sequence":"additional","affiliation":[{"name":"Department of Urology and Oncological Urology Medical University of Lublin  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0168-1701","authenticated-orcid":false,"given":"Joanna","family":"Depciuch","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Physics Polish Academy of Sciences  Krak\u00f3w Poland"},{"name":"Department of Biochemistry and Molecular Biology Medical University of Lublin  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.08.005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06920-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345\u2010011\u20100801\u20101"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2023.04.021"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198710083171501"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.06.046"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.4669"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/21681805.2016.1201858"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016152542"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.21135"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/membranes11080591"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604753"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2020.101923"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202400278"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b04421"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5b00892"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/05704920701829043"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0mb00041h"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/b304883g"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8AN01929K"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.30408"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep08758"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.03.031"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0065\u20102423(08)60334\u20100"},{"issue":"3","key":"e_1_2_9_27_1","first-page":"82","article-title":"Cellular and Molecular Mechanisms Underlying Prostate Cancer Developments: Therapeutic Implications","volume":"6","author":"Testa U.","year":"2019","journal-title":"Medicines (Basel)"}],"container-title":["Journal of Biophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.70046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T23:49:04Z","timestamp":1757029744000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.70046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,21]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/jbio.70046"],"URL":"https:\/\/doi.org\/10.1002\/jbio.70046","archive":["Portico"],"relation":{},"ISSN":["1864-063X","1864-0648"],"issn-type":[{"value":"1864-063X","type":"print"},{"value":"1864-0648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,21]]},"assertion":[{"value":"2024-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70046"}}