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PBM was applied to the temporomandibular joint (TMJ) region, masseter, temporal, scalene, and trapezius muscles over six non\u2010consecutive sessions over 2\u2009weeks. The Research Diagnostic Criteria for Temporomandibular Disorders (DC\/TMD) were used to determine the presence of TMD. A caliper and goniometer were used to measure the mandibular and cervical range of motion, respectively. Pain was assessed with the visual analog scale (VAS) before and after intervention. Results showed pain reduction only in the LED group post\u2010intervention; the placebo group showed no difference. No differences were observed in mouth opening, right laterality, flexion, or extension between groups, but left laterality increased in the LED group. In conclusion, PBM with LEDs effectively reduced pain in TMD patients.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    identifier: NCT06068959\n                  <\/jats:p>","DOI":"10.1002\/jbio.70243","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:32:47Z","timestamp":1772998367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp>LED<\/scp>\n                    Photobiomodulation for Pain Reduction in Temporomandibular Disorder: A Randomized, Controlled, and Blinded Clinical Trial"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9116-1250","authenticated-orcid":false,"given":"Luc\u00eda 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