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In this study, we investigated OKE in Alzheimer's disease (AD) and normal human brain tissues from the hippocampus and Brodmann areas 9 and 17. The Kerr signals from both AD and normal samples exhibited a distinct double\u2010peak profile, corresponding to the electronic and plasma mechanisms. Analysis of plasma relaxation and dielectric response times revealed that conductivity in the AD hippocampus was approximately 46%\u201361% higher than in normal tissue, due to an increase in structural inhomogeneity, which may arise from tau and amyloid\u2010beta (A\u03b2) protein accumulation and elevated water content. Overall, the mean conductivity across the three regions was 38% higher in AD compared to normal tissue. These findings demonstrate that OKE can provide valuable information on underlying molecular mechanisms of the brain that occur on ultrafast timescale.<\/jats:p>","DOI":"10.1002\/jbio.70244","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T01:54:15Z","timestamp":1773453255000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Femtosecond Optical Kerr Effect in Alzheimer's Brain Tissue"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1041-910X","authenticated-orcid":false,"given":"Sandra","family":"Mamani","sequence":"first","affiliation":[{"name":"Department of Physics, Institute for Ultrafast Spectroscopy and Lasers The City College of the City University of New York  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8195-242X","authenticated-orcid":false,"given":"Laura A.","family":"Sordillo","sequence":"additional","affiliation":[{"name":"Department of Physics, Institute for Ultrafast Spectroscopy and Lasers The City College of the City University of New York  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3206-5736","authenticated-orcid":false,"given":"Robert R.","family":"Alfano","sequence":"additional","affiliation":[{"name":"Department of Physics, Institute for Ultrafast Spectroscopy and Lasers The City College of the City University of New York  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.1652962"},{"key":"e_1_2_10_3_1","article-title":"Action d'une onde lumineuse intense sur l'indice de refraction des liquides","volume":"258","author":"Mayer G.","year":"1964","journal-title":"Comptes Rendus de l'Acad\u00e9mie des Sciences"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.24.584"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevA.6.433"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijleo.2021.167872"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-06197-4"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijleo.2024.172134"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0673-42"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevA.20.2170"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevA.21.1730"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/j100292a008"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.optcom.2022.128806"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.optcom.2024.130773"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1088\/0034-4885\/60\/2\/002"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13392"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202300344"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202300099"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113320"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2238-1384"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01911-3"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4896722"},{"key":"e_1_2_10_23_1","article-title":"The Extreme Nonlinear Optics of Gases and Femtosecond Optical Filamentation","volume":"23","author":"Spiers B.","year":"2020","journal-title":"Physical Review Accelerators and Beams"},{"key":"e_1_2_10_24_1","volume-title":"Introduction to Electrodynamics","author":"Griffiths D. 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