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Recently, our previous research demonstrated that mid\u2010infrared femtosecond lasers tuned to the collagen resonance wavelength can selectively ablate solid tumors. However, the mechanisms underlying selectivity, as well as its potential clinical relevance, remain insufficiently understood. In this study, systematic investigations have been conducted on three orthotopic mice models of solid tumors: glioma, pancreatic ductal adenocarcinoma (PDAC), and colorectal cancer, employing a 6.1\u2009\u03bcm femtosecond laser resonant with collagen. Selective ablation is observed in glioma and PDAC, but not in colorectal cancer, which is attributed to the markedly increased collagen content, particularly Collagen I, relative to their corresponding normal tissues, a disparity that is not present in colorectal cancer. Further analysis of clinical specimens through multiplex immunofluorescence and gene expression supports the translational potential of this collagen\u2010mediated selective laser ablation mechanism, suggesting its applicability for tumor\u2010targeted therapeutic interventions.<\/jats:p>","DOI":"10.1002\/jbio.70250","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T16:18:41Z","timestamp":1773159521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Selective Laser Ablation of Malignant Solid Tumors Tuned to the Resonant Wavelength of Collagen"],"prefix":"10.1002","volume":"19","author":[{"given":"Xing","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Pancreatic Surgery, Department of General Surgery West China Hospital, Sichuan University  Chengdu 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