{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T01:45:58Z","timestamp":1774921558168,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["R.11017\/15\/2023\u2010GIA\/HR"],"award-info":[{"award-number":["R.11017\/15\/2023\u2010GIA\/HR"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2022\/001404"],"award-info":[{"award-number":["CRG\/2022\/001404"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We present a custom\u2010built, high\u2010speed optical coherence elastography (OCE) system for non\u2010invasive, quantitative assessment of oral tissue biomechanics. The system integrates low\u2010frequency (10\u2009Hz) air\u2010driven elastic wave excitation with phase\u2010resolved optical coherence tomography (OCT) for micrometer\u2010scale elasticity mapping. A pilot study on human buccal mucosa (four healthy, four cancerous, one leukoplakia) revealed distinct biomechanical contrasts. Healthy tissues exhibited regular elastic wave propagation (\u22482.5\u2009\u03bcm displacement; 2.72\u2009\u00b1\u20090.27\u2009Pa modulus), while cancerous samples showed restricted displacement (\u22481\u2009\u03bcm; 9.51\u2009\u00b1\u20090.95\u2009Pa), indicating increased stiffness. The elastograms also visualized keratin layer thickening, rete peg elongation, and mild inflammatory infiltration. The leukoplakia specimen demonstrated intermediate stiffness (5.47\u2009\u00b1\u20090.55\u2009Pa), suggestive of early biomechanical alteration. The integration of air\u2010pressure excitation with phase\u2010resolved OCT enables a non\u2010contact, repeatable, and sensitive elastographic method capable of detecting subtle mechanical changes, highlighting the system's potential for early oral cancer diagnosis and soft tissue biomechanical characterization.<\/jats:p>","DOI":"10.1002\/jbio.70255","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T01:34:17Z","timestamp":1774488857000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Micrometer\u2010Scale Biomechanical Characterization of Oral Mucosa Using Spatial Phase\u2010Gradient Tracking Optical Coherence Elastography"],"prefix":"10.1002","volume":"19","author":[{"given":"Sweta","family":"Satpathy","sequence":"first","affiliation":[{"name":"Biophotonics Lab, Department of Bioengineering and Biotechnology Birla Institute of Technology  Mesra, Ranchi Jharkhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arpita","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Dentistry Rajendra Institute of Medical Science  Ranchi Jharkhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priya","family":"Shree","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology Vananchal Dental College  Garhwa Jharkhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6945-9555","authenticated-orcid":false,"given":"Raju","family":"Poddar","sequence":"additional","affiliation":[{"name":"Biophotonics Lab, Department of Bioengineering and Biotechnology Birla Institute of Technology  Mesra, Ranchi Jharkhand 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