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Photobiomodulation (PBM) and platelet\u2010rich fibrin (PRF) have emerged as therapeutic approaches due to their regenerative potential, although their mechanisms during tendon healing remain unclear. This study compared the effects of PBM and PRF, alone or combined, on experimentally induced calcaneal tendinopathy in rats. A total of 75 animals were divided into five groups: control, injury, PRF, PBM, and PRF\u2009+\u2009PBM. Treatments began 48\u2009h after injury. Functional performance, nociception, and histological features were evaluated up to 21\u2009days. Combined PRF and PBM promoted superior early functional recovery, enhanced collagen synthesis, and increased angiogenesis, despite greater initial inflammation. PBM alone resulted in gradual recovery with better fiber organization, while PRF accelerated function but sustained inflammation. Combined therapy shows promise for tendon repair, supporting stage\u2010specific treatment strategies.<\/jats:p>","DOI":"10.1002\/jbio.70271","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T03:25:28Z","timestamp":1776655528000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Therapeutic Effect of Photobiomodulation and Single Intratendinous Injection at the Lesion Site of Platelet\u2010Rich Fibrin in Inducted Tendinopathy"],"prefix":"10.1002","volume":"19","author":[{"given":"Caroline Hammerschmitt","family":"Wild","sequence":"first","affiliation":[{"name":"Universidade Estadual Do Oeste Do Paran\u00e1 \u2013 UNIOESTE \u2013 Cascavel  Cascavel Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e2mela Andressa","family":"Pauletto","sequence":"additional","affiliation":[{"name":"Universidade Estadual Do Oeste Do Paran\u00e1 \u2013 UNIOESTE \u2013 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