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Transcorneal electrical stimulation (TES) has emerged as a noninvasive neuromodulation approach, yet its effects on AD\u2010related pathology and eye\u2013brain interactions remain unclear. In this study, TES was applied to wild\u2010type (WT) and AD mice, followed by longitudinal optical coherence tomography (OCT) and OCT angiography (OCTA) imaging of the retina and cerebral cortex over a 30\u2010day period. Quantitative imaging metrics, together with histologically assessed amyloid\u2010\u03b2 (A\u03b2) plaque deposition, were used to assess TES\u2010associated structural and neurovascular changes. In addition to retinal thickness, retinal vascular density (VD) was evaluated as an objective, noninvasive imaging metric associated with AD\u2010related neurovascular alterations. These findings demonstrate the utility of longitudinal OCT\/OCTA imaging for investigating intervention\u2010associated retinal and cerebral neurovascular changes along the eye\u2013brain axis.<\/jats:p>","DOI":"10.1002\/jbio.70274","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T22:59:26Z","timestamp":1778021966000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of the Therapeutic Effects of Transcorneal Electrical Stimulation on Alzheimer's Disease Using Optical Coherence Tomography"],"prefix":"10.1002","volume":"19","author":[{"given":"Ping","family":"Si","sequence":"first","affiliation":[{"name":"College of Sciences Shanghai Institute of Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7492-633X","authenticated-orcid":false,"given":"Ni","family":"He","sequence":"additional","affiliation":[{"name":"College of Sciences Shanghai Institute of Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabiao","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Sciences Shanghai Institute of Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyun","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Sciences Shanghai Institute of Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingchao","family":"Lin","sequence":"additional","affiliation":[{"name":"Metabo\u2010Profile Biotechnology (Shanghai) Co., Ltd  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuixia","family":"Dai","sequence":"additional","affiliation":[{"name":"College of Sciences Shanghai Institute of Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X18666200528142429"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01314-6"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/15672050113109990155"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e20604"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14219"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(01)00620-4"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.572484"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wno.0000204645.56873.26"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58399-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0255362"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200913"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57030215"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2023.1134857"},{"issue":"1","key":"e_1_2_10_16_1","first-page":"163","article-title":"Transcorneal Electrical Stimulation Induced Antidepressant\u2010Like Effects in S334ter\u2010Line\u20103 Rat Model of Retinal Degeneration","volume":"14","author":"Yu W. 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