{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T05:02:15Z","timestamp":1779944535602,"version":"3.53.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["No. 24JCZDJC00730"],"award-info":[{"award-number":["No. 24JCZDJC00730"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Nos. 52307255"],"award-info":[{"award-number":["Nos. 52307255"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["Nos. 2023YFF1203700 and 2023YFF1203701"],"award-info":[{"award-number":["Nos. 2023YFF1203700 and 2023YFF1203701"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This study applied the Interferometric Diffusion Speckle Contrast Analysis (iDSCA) system developed by our research group to detect changes in common carotid artery blood flow. Through animal experiments combining color Doppler ultrasound and human in\u00a0vivo experiments integrating Transcranial Doppler, the iDSCA system was validated as a technical modality for early warning of ischemic stroke.<\/jats:p>\n                  <jats:p>The experimental results show that in animal experiments, the average relative blood flow index change rate detected by iDSCA after stenosis is \u221256.66%, which is consistent with the detection result of color Doppler ultrasound (\u221263.17%). In human in\u00a0vivo experiments, the average rBFI (%) detected by iDSCA was \u221223.38%, consistent with the average rate of change in blood flow velocity (rMV(%)\u2009=\u2009\u221220.43%) measured by TCD.<\/jats:p>\n                  <jats:p>The iDSCA system has demonstrated significant correlation in both animal and in\u00a0vivo experiments, confirming its ability to noninvasively and sensitively capture hemodynamic changes caused by CCA stenosis.<\/jats:p>","DOI":"10.1002\/jbio.70277","type":"journal-article","created":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T22:38:28Z","timestamp":1779057508000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Research on Carotid Blood Flow Detection Based on Interferometric Diffuse Speckle Contrast Analysis and Its Application in Preventing Ischemic Stroke"],"prefix":"10.1002","volume":"19","author":[{"given":"Guang","family":"Han","sequence":"first","affiliation":[{"name":"School of Life Science, Tiangong University  Tianjin China"},{"name":"Tianjin Key Laboratory of Control and Evaluation Technology for Medical Devices  Tianjin China"},{"name":"Beijing Key Laboratory of Intelligent Emergency Medical Rescue  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Electronics and Information Engineering, Tiangong University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglong","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Life Science, Tiangong University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijuan","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Life Science, Tiangong University  Tianjin 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4346-5329","authenticated-orcid":false,"given":"Zhe","family":"Zhao","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Control and Evaluation Technology for Medical Devices  Tianjin China"},{"name":"Beijing Key Laboratory of Intelligent Emergency Medical Rescue  Beijing China"},{"name":"School of Electronics and Information Engineering, Tiangong University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.16106\/j.cnki.cn14\u20101281\/r.2025.02.015"},{"key":"e_1_2_11_3_1","first-page":"10214","volume-title":"Temporal Statistical Analysis of Laser Speckle Images and Its Application to Retinal Blood\u2010Flow Imaging","author":"Cheng 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