{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T05:02:04Z","timestamp":1779944524872,"version":"3.53.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This pilot randomized clinical trial evaluated photodynamic therapy (PDT) in diabetic foot ulcers (DFUs), comparing an intervention group (IG,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095) with a control group (CG,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20094). Participants were followed for 7\u2009weeks. The IG received PDT, while the CG underwent conventional care. The microbiological profile was assessed by biopsy before and after treatment, and wound progression was evaluated using the Bates\u2010Jensen Wound Assessment Tool. In the IG, only one participant showed an increase in the number of bacterial species, while the others maintained the count with changes in species composition. In the CG, two participants presented an increase in bacterial species. All participants in the IG showed a reduction in ulcer size, with an average decrease of more than 63%, whereas two participants in the CG exhibited an increase in lesion area. These results suggest clinically relevant differences, supporting PDT as a promising adjuvant strategy for antimicrobial stewardship in DFUs.\n                  <\/jats:p>","DOI":"10.1002\/jbio.70278","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:20:14Z","timestamp":1778541614000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antimicrobial Photodynamic Therapy in the Treatment of Diabetic Foot Ulcers: A Pilot Randomized Clinical Trial"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9925-4750","authenticated-orcid":false,"given":"Maria Girlane Sousa Albuquerque","family":"Brand\u00e3o","sequence":"first","affiliation":[{"name":"Institute of Health Sciences University of International Integration of Afro\u2010Brazilian Lusophony \u2013 UNILAB  Reden\u00e7\u00e3o Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7955-4484","authenticated-orcid":false,"given":"Mayra Gon\u00e7alves","family":"Menegueti","sequence":"additional","affiliation":[{"name":"Department of General and Specialized Nursing, School of Nursing University of S\u00e3o Paulo at Ribeir\u00e3o Preto  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Bueno","family":"Filho","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas of the Faculty of Medicine of the University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano Rocha","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Portuguese Beneficence Hospital of Ribeir\u00e3o Preto  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina","family":"Gomes","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas of the Faculty of Medicine of the University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8024-2074","authenticated-orcid":false,"given":"Idevania G.","family":"Costa","sequence":"additional","affiliation":[{"name":"School of Nursing Lakehead University  Thunder Bay Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraia Assad Nasbine","family":"Rabeh","sequence":"additional","affiliation":[{"name":"Department of General and Specialized Nursing, School of Nursing University of S\u00e3o Paulo at Ribeir\u00e3o Preto  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201078215\u20107"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.17291"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/WON.0000000000000941"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3280"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.31011\/reaid\u20102022\u2010v.96\u2010n.39\u2010art.1365"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2024.104228"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202300412"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/1516\u20103180.2022.0476.27022023"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.7573\/dic.2019\u201010\u20103"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2024.0013"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEOR.S274897"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.33235\/wcet.44.4.28\u201038"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2017.430"},{"issue":"2","key":"e_1_2_11_15_1","first-page":"58","article-title":"Tradu\u00e7\u00e3o das recomenda\u00e7\u00f5es do International Working Goup on the Diabetic Foot (IWGDF) pelo Grupo de Estudos de P\u00e9 Diab\u00e9tico (GEPED) da Sociedade Portuguesa de Diabetologia","volume":"15","author":"Carvalho R.","year":"2020","journal-title":"Revista Portuguesa de Diabetes"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1590\/0104\u201007072015001990014"},{"key":"e_1_2_11_17_1","volume-title":"Efeitos biol\u00f3gicos produzidos pela terapia fotodin\u00e2mica na repara\u00e7\u00e3o de feridas diab\u00e9ticas em humanos. 127 f. 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