{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:04:31Z","timestamp":1784192671528,"version":"3.55.0"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:00:00Z","timestamp":1780790400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 114\u20102923\u2010E\u2010468\u2010001\u2010MY3"],"award-info":[{"award-number":["NSTC 114\u20102923\u2010E\u2010468\u2010001\u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 114\u20102410\u2010H\u2010468\u2010016"],"award-info":[{"award-number":["NSTC 114\u20102410\u2010H\u2010468\u2010016"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study evaluated the short\u2010term biomechanical response of wound tissue following low\u2010level laser therapy (LLLT) by examining changes in skin stiffness, a surrogate biomechanical indicator of short\u2010term tissue response, across different limb regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 660\u2009nm LLLT protocol was applied to wound sites. Skin stiffness was quantified using optical coherence tomography (OCT) combined with an air\u2010jet indentation system, enabling non\u2010contact measurement of tissue deformation. For accurate layer\u2010specific assessment, a U\u2010Net\u2013based model was employed to automate OCT image segmentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The automated segmentation by the U\u2010Net model achieved a segmentation accuracy of 92%, facilitated precise segmentation of skin layers. LLLT significantly reduced skin stiffness after treatment, indicating an acute modulation of tissue compliance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Short\u2010duration LLLT reduces skin stiffness immediately post\u2010treatment, indicating its potential as a non\u2010invasive intervention to modulate the biomechanical environment of wounds.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT07177274\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jbio.70291","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:35:31Z","timestamp":1780878931000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deep Learning\u2010Based\n                    <scp>OCT<\/scp>\n                    Segmentation for Stiffness Quantification in Evaluating Low\u2010Level Laser Therapy for Wound Healing"],"prefix":"10.1002","volume":"19","author":[{"given":"Gilang Titah","family":"Ramadhan","sequence":"first","affiliation":[{"name":"Department of Informatics Tiga Serangkai University  Surakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7149-4034","authenticated-orcid":false,"given":"Yih\u2010Kuen","family":"Jan","sequence":"additional","affiliation":[{"name":"Rehabilitation Engineering Lab, Department of Health and Kinesiology University of Illinois at 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