{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:04:23Z","timestamp":1784192663154,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102023\u201000251928"],"award-info":[{"award-number":["RS\u20102023\u201000251928"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Mitochondrial dysfunction and oxidative stress in retinal ganglion cells (RGCs) are critical events in the pathogenesis of glaucoma that occur prior to structural degeneration and visual field loss. Flavoprotein fluorescence (FPF) produced by oxidized mitochondrial flavoproteins offers a potential biomarker for early detection of cellular dysfunction. This study investigated the feasibility of performing FPF imaging in a rodent glaucoma model and its integration with a real\u2010time optical coherence tomography (OCT) alignment monitor that verifies on\u2010retina focus during fluorescence acquisition. A scanning laser ophthalmoscope\u2010OCT system was constructed, with two photomultiplier tubes to differentiate FPF from lipofuscin autofluorescence. In the rodent glaucoma model induced by intracameral magnetic bead injection, FPF signals were detected under 450\u2010nm excitation, while 505\u2010nm excitation produced no signal. This proof\u2010of\u2010concept work demonstrates that in\u00a0vivo retinal FPF imaging is feasible in this glaucoma model, which may facilitate early detection of RGC dysfunction at a cellular level.<\/jats:p>","DOI":"10.1002\/jbio.70297","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T08:01:02Z","timestamp":1780041662000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of In\u00a0Vivo Retinal Flavoprotein Autofluorescence Imaging in a Magnetic\u2010Bead\u2010Induced Rodent Glaucoma Model"],"prefix":"10.1002","volume":"19","author":[{"given":"Eun Ji","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Seoul National University College of Medicine, Seoul National University Bundang Hospital  Seongnam Republic of Korea"},{"name":"Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwon","family":"Kang","sequence":"additional","affiliation":[{"name":"Philophos  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Ho","family":"Chung","sequence":"additional","affiliation":[{"name":"Philophos  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Seoul National University Boramae Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Jin","family":"Roh","sequence":"additional","affiliation":[{"name":"HanGil Eye Hospital  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Kyun","family":"Han","sequence":"additional","affiliation":[{"name":"HanGil Eye Hospital  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2012.09.008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e328349419d"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2011.607536"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/27.1.438504"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)30079-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-020-1110-y"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fopht.2023.1110501"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/13816810.2022.2144903"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogla.2021.12.006"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0317354"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2025.2527755"},{"issue":"8","key":"e_1_2_8_13_1","first-page":"5022","article-title":"Reproducibility of Retinal Mitochondrial Imaging Using Flavoprotein Fluorescence in Glaucoma Patients and Suspects","volume":"64","author":"Kim J. 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