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Most existing clinical and biomedical studies still rely on subjective inflammatory assessment and semiquantitative molecular evaluation, and there is very little fairness research on multidimensional uveitis characterization exploration. With the advent of noninvasive and high\u2010resolution imaging technology, there is a growing demand for objective, quantitative, and traceable indicators to support mechanistic investigation, accurate staging, precision therapy, and early relapse detection. In this study, we implemented a multiparametric, multimodal imaging platform to longitudinally monitor experimental autoimmune uveitis (EAU). Changes in retinal structure, vascular networks, and visual function were evaluated within 2\u2009weeks after EAU induction. Based on quantitative analysis of optical coherence tomography (OCT), OCT angiography (OCTA), vascular density (VD), and vascular tortuosity (VT) were shown to correlate with retinal thickness, clinical scores, histopathological scores, and may be added as potential objective and noninvasive candidate indicators for uveitis detection.<\/jats:p>","DOI":"10.1002\/jbio.70301","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:20:50Z","timestamp":1780410050000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multimodal Imaging\u2010Based Quantitative Assessment of Autoimmune Uveitis in Experimental Mouse Model"],"prefix":"10.1002","volume":"19","author":[{"given":"Xiaolong","family":"Zhang","sequence":"first","affiliation":[{"name":"Shanghai Institute of Technology College of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Ophthalmology and Optometry Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4297-962X","authenticated-orcid":false,"given":"Meixiao","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Ophthalmology and Optometry Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6443-7058","authenticated-orcid":false,"given":"Zi","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Ophthalmology and Optometry Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Technology College of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuixia","family":"Dai","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Technology College of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2019.107853"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2015.07.001"},{"key":"e_1_2_10_4_1","first-page":"475","article-title":"AB0971 A Case of Pediatric Idiopathic Calcinosis","volume":"21","author":"Gamalero L.","year":"2019","journal-title":"Israel Medical Association Journal"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.31936"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.06.012"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100866"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200565040-00005"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00659-0"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)03392-8"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200501000-00001"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000119871"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-720-4_22"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1993.1057"},{"key":"e_1_2_10_15_1","first-page":"3177","article-title":"Macrophages and Dendritic Cells in IRBP\u2010Induced Experimental Autoimmune Uveoretinitis in B10RIII Mice","volume":"40","author":"Jiang H. 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