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While Optical Clearing Agents (OCAs) are used to reduce skin attenuation, Mechanical Compression (MC) is also applied in clinical settings despite its inconclusive results. Their relative effectiveness under standardized conditions remains poorly characterized. This study quantitatively compares various OCA formulations, including mineral oil, PEG\u2010400, fructose, and tartrazine, with enhancers such as oleic acid and 1,2\u2010propanediol, under load\u2010dependent MC (1.6\u201347\u2009kPa). Using spectral\u2010domain OCT at 840\u2009nm on porcine skin, we found that PEG\u2010400\/oleic acid (80\/20%) achieved the highest efficiency, reducing the optical attenuation coefficient (OAC) by 23.8%\u2009\u00b1\u20091.7% within 15\u2009min. Fructose\u2010based and aqueous tartrazine formulations also showed significant reductions (16.8% and 20.4%). Conversely, our results show that MC does not effectively reduce skin optical attenuation. 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