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Unstimulated saliva samples were collected from 57 patients with lung cancer and 36 healthy controls. TEM and DLS revealed increased heterogeneity of the salivary colloidal fraction and a shift toward larger particle populations in lung cancer. UV\u2013Vis spectroscopy showed a hypsochromic shift of the main absorption peak (279\u2013261\u2009nm), while fluorescence intensity at 510\u2009nm increased 1.9\u2010fold with additional emission bands at 617 and 680\u2009nm. Reflectance decreased across the measured spectral range. ATR\u2010FTIR identified the Amide III\/asymmetric PO\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    region (1350\u20131180\u2009cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) as the most discriminative interval (AUC\u2009=\u20090.854). Fluorescence\u2010based classification achieved an AUC of 0.706, with 73.1% sensitivity and 76.3% specificity.\n                    <jats:sup>1<\/jats:sup>\n                    H NMR revealed alterations in metabolites associated with metabolic reprogramming.\n                  <\/jats:p>","DOI":"10.1002\/jbio.70333","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T08:42:56Z","timestamp":1785314576000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Study of the Spectral\u2010Luminescent Properties of Saliva in Patients With Lung Cancer"],"prefix":"10.1002","volume":"19","author":[{"given":"K. 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