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However, many of these functions are reduced with aging and can be accentuated in photoaged skin. Photodynamic therapy (PDT) is a noninvasive technique used in the treatment of cancer, microbial infections, precancerous changes and for cosmetic purposes. Research on topical PDT suggests antibacterial, anti\u2010inflammatory and immunomodulatory effects on keratinocytes, fibroblasts, sebaceous glands and hair follicles. Therefore, this pilot study evaluated PDT on the face using 5\u2010aminolevulinic acid (ALA) and methyl 5\u2010aminolevulinate (MAL), combined with amber LED and laser irradiation in women aged 40\u201355\u2009years. PDT was effective in rejuvenating photoaged skin, reducing fine lines, smoothing wrinkles, and improving skin softness, firmness and sagging, with minimal side effects.<\/jats:p>","DOI":"10.1002\/jbio.70335","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T23:11:06Z","timestamp":1786403466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photodynamic Therapy for Facial Rejuvenation Combined Amber\n                    <scp>LED<\/scp>\n                    and Infrared Laser Irradiation: A Pilot Study Comparing\n                    <scp>ALA<\/scp>\n                    and\n                    <scp>MAL<\/scp>"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0114-4658","authenticated-orcid":false,"given":"Tassia Joi","family":"Martins","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Fotobiologia Aplicada \u00e0 Sa\u00fade 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