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Monitoring of acne progression can improve understanding of lesion evolution, support evaluation of treatment response and provide potential biomarkers for future investigation of acne sequelae. This study presents a multi\u2010functional optical coherence tomography (OCT) protocol integrating structural imaging, OCT\u2010based angiography (OCTA), and optical coherence elastography (OCE) for longitudinal in\u00a0vivo monitoring of acne. Thirteen lesions were evaluated across eight time points over 18\u2009days. Quantitative parameters, including Young's modulus and vascular metrics, captured biomechanical and microvascular changes during acne evolution. The system enables continuous multimodal assessment, showing that stiffness and vascular alterations reflect lesion progression. This pilot longitudinal study establishes a quantitative foundation for dermatological research and suggests that multimodal OCT monitoring may provide biomarkers for assessing lesion progression and long\u2010term clinical outcomes.<\/jats:p>","DOI":"10.1002\/jbio.70337","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T03:16:58Z","timestamp":1786677418000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["In Vivo Monitoring of Facial Acne Development by Using Multimodal Functional\n                    <scp>OCT<\/scp>"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4168-6589","authenticated-orcid":false,"given":"Zhengshuyi","family":"Feng","sequence":"first","affiliation":[{"name":"Healthcare Engineering, School of Physics and Engineering Technology University of York  York 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