{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T08:10:57Z","timestamp":1789027857874,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Evaluating the mechanical properties of atherosclerotic plaques is crucial for precisely identifying rupture\u2010prone lesions, as different plaque constituents dictate local biomechanical instability and directly inform targeted therapeutic intervention. In this study, we further achieved quantitative photoacoustic elasticity imaging (PAEI) and photoacoustic viscosity imaging (PAVI) by analyzing the rise time of the thermoelastic displacement and by measuring the phase delay of the photoacoustic signal relative to the laser pulse, respectively. Experiments on mice aortas have shown that PAVI is more sensitive to the changes in lipid core area during lipid plaque stage, whereas PAEI is more effective at detecting changes in fibrous cap thickness during fibrous plaque stage. Furthermore, PAEI and PAVI can effectively distinguish lipid plaques and fibrous plaques from normal vascular tissue. All results indicate that the PAEI\u2013PAVI imaging system enables label\u2010free, high\u2010resolution visualization of the component\u2010based biomechanical properties of atherosclerotic plaques, facilitating early detection and rupture risk assessment.<\/jats:p>","DOI":"10.1002\/jbio.70342","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T07:16:35Z","timestamp":1787210195000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative Assessment of Composition\u2010Dependent Mechanical Properties of Atherosclerotic Plaques by Photoacoustic Elasticity and Viscosity Imaging"],"prefix":"10.1002","volume":"19","author":[{"given":"Ao","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine School of Medicine, Shaoxing University  Shaoxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine School of Medicine, Shaoxing University  Shaoxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiting","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine School of Medicine, Shaoxing University  Shaoxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1624-8927","authenticated-orcid":false,"given":"Heng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine School of Medicine, Shaoxing University  Shaoxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3614-8339","authenticated-orcid":false,"given":"Pingping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine School of Medicine, Shaoxing University  Shaoxing China"},{"name":"MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, South China Normal University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00413-6"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/bios13030319"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21082992"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1924-7_52"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2020.05.013"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-013-0888-1"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202400251"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-026-69808-z"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054802"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab046"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06206-z"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.09.029"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202100299"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202200313"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.39.003970"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.6.004975"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.390874"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.39.002565"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.5001272"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.5051387"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2024.3368150"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.5021675"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2019.2958112"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pacs.2023.100581"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-5629(98)00110-0"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/photonics12010090"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3157193"},{"issue":"6","key":"e_1_2_11_29_1","first-page":"631","article-title":"Acoustic Radiation Force Impulse (ARFI) Elastography in Evaluation of Supraspinatus Tendinopathy","volume":"19","author":"Serifoglu I.","year":"2023","journal-title":"Current Medical Imaging"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1109\/TUFFC.2022.3189184"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.36.003341"},{"issue":"3","key":"e_1_2_11_32_1","first-page":"356","article-title":"Ultrasound Elastography: Another Piece in the Puzzle of Carotid Plaque Vulnerability?","volume":"24","author":"Davidhi A.","year":"2022","journal-title":"Medical Ultrasonography"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202300292"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-021-03324-0"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.5.1262"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03392-8"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.24.4.040901"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.42.004974"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.23.3.036007"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.458383"}],"container-title":["Journal of Biophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.70342","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbio.70342","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.70342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:58:38Z","timestamp":1789027118000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.70342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/jbio.70342"],"URL":"https:\/\/doi.org\/10.1002\/jbio.70342","archive":["Portico"],"relation":{},"ISSN":["1864-063X","1864-0648"],"issn-type":[{"value":"1864-063X","type":"print"},{"value":"1864-0648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70342"}}