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The method integrates Mach\u2013Zehnder interferometry, digital holographic reconstruction of complex amplitudes, phase\u2010selective speckle\u2010field analysis, and statistical\u2013multifractal processing of Jones\u2010matrix images. Unlike intensity\u2010based Stokes polarimetry, it provides amplitude and phase information and enables selective analysis of the coherent ballistic or weakly scattered polarization\u2010preserving field component. Analytical relationships between real and imaginary Jones\u2010matrix components and linear\/circular birefringence mechanisms establish their interpretation as markers of spatial heterogeneity, orientational consistency, and phase organization of supramolecular polycrystalline networks. Using bile films, phase\u2010selective mapping revealed distinct anisotropy manifestations in dendritic and spherulitic structures. Higher\u2010order statistical moments and multifractal spectra described coordinate\u2010 and scale\u2010dependent transformations. Primary validation on bile, whole blood, and dental canal irrigation films showed comparable integral\u2010field accuracy but higher Jones\u2010matrix informativeness after minimally scattered component isolation, supporting label\u2010free biomedical diagnostics requiring further clinical validation.<\/jats:p>","DOI":"10.1002\/jbio.70349","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T07:28:42Z","timestamp":1788852522000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polarization Biophotonics of Hidden Multifractal Structures in Soft Matter Layers for Biomedical Diagnostics"],"prefix":"10.1002","volume":"19","author":[{"given":"Yuriy","family":"Ushenko","sequence":"first","affiliation":[{"name":"Department of Physics Shaoxing University  Shaoxing Zhejiang China"},{"name":"Computer Science Department Chernivtsi National University  Chernivtsi 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