{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:56:19Z","timestamp":1790556979767,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study numerically investigates a D\u2010shaped photonic crystal fiber (PCF) surface plasmon resonance (SPR) sensor integrated with an Au\u2010TiO\n                    <jats:sub>2<\/jats:sub>\n                    micro\u2010grating metastructure for SARS\u2010CoV\u20102\u2010related biomolecular interaction analysis. The grating modulates phase matching between the core\u2010guided and surface plasmon polariton modes, enhancing the refractive index (RI) response. The finite element method (FEM) was used to optimize the PCF air\u2010hole diameters and Au\u2010TiO\n                    <jats:sub>2<\/jats:sub>\n                    grating parameters. The sensor shows a broad RI response range of 1.19\u20131.43, with a maximum local wavelength sensitivity (WS) of 18\u2009500\u2009nm\/RIU, minimum full width at half maximum (FWHM) of 10\u2009nm, and maximum figure of merit (FOM) of 240 RIU\n                    <jats:sup>\u22121<\/jats:sup>\n                    . For modeled spike RBD and anti\u2010RBD monoclonal IgG binding, maximum WS values of 5000 and 4782\u2009nm\/RIU were obtained. These results support compact fiber\u2010integrated SPR platforms for label\u2010free monitoring of SARS\u2010CoV\u20102\u2010related RI variations, while specificity and reliability require experimental validation.\n                  <\/jats:p>","DOI":"10.1002\/jbio.70350","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:23:12Z","timestamp":1790385792000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Numerical Investigation of an Au\u2010\n                    <scp>\n                      TiO\n                      <sub>2<\/sub>\n                    <\/scp>\n                    Micro\u2010Grating\u2010Metastructure D\u2010Shaped\n                    <scp>PCF<\/scp>\n                    \u2010\n                    <scp>SPR<\/scp>\n                    Sensor for\n                    <scp>SARS<\/scp>\n                    \u2010\n                    <scp>CoV<\/scp>\n                    \u20102\u2010Related Biomolecular Interaction Analysis"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9871-9175","authenticated-orcid":false,"given":"Xing","family":"Wang","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Film Electronic and Communication Devices, School of Integrated Circuit Science and Engineering, Tianjin University of Technology  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honggang","family":"Pan","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Film Electronic and Communication Devices, School of Integrated Circuit Science and Engineering, Tianjin University of Technology  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Xia","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Film Electronic and Communication Devices, School of Integrated Circuit Science and Engineering, Tianjin University of Technology  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingcheng","family":"You","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Film Electronic and Communication Devices, School of Integrated Circuit Science and Engineering, Tianjin University of Technology  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Film Electronic and Communication Devices, School of Integrated Circuit Science and Engineering, Tianjin University of Technology  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6383-3492","authenticated-orcid":false,"given":"Licui","family":"Ji","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Film Electronic and Communication Devices, School of Integrated Circuit Science and Engineering, 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