{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:56:20Z","timestamp":1790556980460,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Effective excitation of cerebrovascular photoacoustic signals is limited by superficial tissue attenuation and illumination geometry. This paper proposes a multi\u2010source illumination evaluation method for gray\u2010matter vessel targets based on Monte Carlo light transport and photoacoustic initial\u2010pressure calculation using a simplified multilayer brain model for screening and a Tissue Probability Map (TPM) brain model for validation. The dual Collimated Gaussian source with 15\u00b0 symmetric incidence along the Y direction performed best in the regular layered model, whereas the dual Pencil Array source with 20\u00b0 symmetric incidence along the Y direction was optimal in the TPM model. These results suggest that regular layered models are suitable for preliminary screening, but the final illumination scheme should be revalidated under anatomical constraints. This study provides a theoretical reference for optimizing optical\u2010source configurations in human brain photoacoustic imaging.<\/jats:p>","DOI":"10.1002\/jbio.70364","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:49:13Z","timestamp":1789645753000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Monte Carlo\u2010Based Optimization of Multi\u2010Source Illumination for Photoacoustic Signal Generation in\u00a0Human Gray\u2010Matter Vessels"],"prefix":"10.1002","volume":"19","author":[{"given":"Jun","family":"Tong","sequence":"first","affiliation":[{"name":"School of Mathematics and Physics Hebei University of Engineering  Handan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Han","sequence":"additional","affiliation":[{"name":"School of Mathematics and Physics Hebei University of Engineering  Handan 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