{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:56:18Z","timestamp":1790556978832,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this work, the effect of surface modification of superparamagnetic iron oxide nanoparticles (SPIONs) with polyethylene glycol (PEG) on contrast enhancement in swept\u2010source optical coherence tomography (SS\u2010OCT) is investigated. The bare and PEGylated SPIONs were prepared by the co\u2010precipitation method from an aqueous solution of an Fe(III) salt. They were characterized by UV\u2010DRS, Raman spectroscopy, FTIR, TEM, and VSM to determine their physicochemical properties. The performance of ex\u00a0vivo imaging was evaluated in chicken breast tissue with B\u2010scan SS\u2010OCT at various exposure times (0, 10, 20, 30, 40, and 50\u2009min), and the contrast enhancement was investigated by measuring the scattering coefficient. The brightness of bare SPIONs was low, and the penetration into tissues was slow. PEG\u2010SPIONs, on the other hand, showed better optical stability, penetration, enhanced scattering, and brighter SS\u2010OCT images. The scattering coefficient (mm\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) of PEG\u2010SPION\u2010treated tissue increased with exposure time, indicating its effectiveness as a tissue contrast agent.\n                  <\/jats:p>","DOI":"10.1002\/jbio.70367","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:55:29Z","timestamp":1790240129000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>PEGylated<\/scp>\n                    Superparamagnetic Iron Oxide Nanoparticles as Contrast\u2010Enhancing Agents for Swept\u2010Source Optical Coherence Tomography of Biological Tissue"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1386-7290","authenticated-orcid":false,"given":"Tejal","family":"Barkhade","sequence":"first","affiliation":[{"name":"Department of Life Sciences, Parul Institute of Applied Sciences Parul University  Vadodara Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gajendar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Physics, Parul Institute of Applied Sciences Parul University  Vadodara Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Indoliya","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Birla Institute of Technology  Ranchi Jharkhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6945-9555","authenticated-orcid":false,"given":"Raju","family":"Poddar","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Birla Institute of Technology  Ranchi Jharkhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6NR07462F"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00112"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00589"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr500698d"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4NR05781C"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmmi.1498"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NR01651G"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201001658"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-015-3216-x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/cm0628000"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/la302446h"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano8100776"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1088\/1555-6611\/aa884b"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b00481"},{"key":"e_1_2_11_16_1","first-page":"128","article-title":"Contrast Enhancement of Optical Coherence Tomography Images Using Branched Gold Nanoparticles","volume":"2012","author":"De Le\u00f3n Y. 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