{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:12:08Z","timestamp":1761675128691},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,4,5]],"date-time":"2002-04-05T00:00:00Z","timestamp":1017964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Mater. Res."],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An appropriate carrier acting as a slow delivery vehicle for the BMPs is required for maximal clinical effectiveness of these bone\u2010inductive proteins. The purpose of this study was to evaluate a low\u2010molecular\u2010weight PLGA copolymer as a synthetic, biodegradable carrier for rhBMP\u20102 implantation <jats:italic>in vivo<\/jats:italic>. Two, 10, or 50 \u03bcg of recombinant human BMP\u20102 were mixed with 10 mg of a poly (<jats:sc>DL<\/jats:sc>\u2010lactide\u2010<jats:italic>co<\/jats:italic>\u2010glycolide) (PLGA) 50:50 copolymer and implanted into the calf muscles of Wistar rats. Soft X\u2010ray analysis and histologic examination indicated that new bone formation occurred at all rhBMP\u20102\u2010implanted sites within 3 weeks after implantation. Correlation of rhBMP\u20102 concentration with the amount of bone induction was confirmed by specific alkaline phosphatase activity and calcium content assay. <jats:italic>In vitro<\/jats:italic> analysis indicated that 78.5% of the PLGA copolymer was degraded to smaller molecular weight material after 14 days in PBS solution. It is suggested that rhBMP\u20102 was released in an active form at the implant site during the degradation of the copolymer, resulting in the induction of new bone formation. Thus this low\u2010molecular\u2010weight PLGA copolymer material represents a promising delivery vehicle for BMPs, and possibly other growth factors, around dental and orthopedic implants. \u00a9 2002 Wiley Periodicals, Inc. J Biomed Mater Res 61: 61\u201365, 2002<\/jats:p>","DOI":"10.1002\/jbm.10169","type":"journal-article","created":{"date-parts":[[2004,10,27]],"date-time":"2004-10-27T10:56:25Z","timestamp":1098874585000},"page":"61-65","source":"Crossref","is-referenced-by-count":48,"title":["Experimental studies on bone induction using low\u2010molecular\u2010weight poly (<scp>DL<\/scp>\u2010lactide\u2010<i>co<\/i>\u2010glycolide) as a carrier for recombinant human bone morphogenetic protein\u20102"],"prefix":"10.1002","volume":"61","author":[{"given":"K.","family":"Bessho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. L.","family":"Carnes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Cavin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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