{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:19:40Z","timestamp":1767651580964},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,9,5]],"date-time":"2002-09-05T00:00:00Z","timestamp":1031184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Mater. Res."],"published-print":{"date-parts":[[2002,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oxidative degradation of ultra\u2010high molecular weight polyethylene (UHMWPE) attributed to sterilization by gamma\u2010radiation in the presence of air has been cited as one of the major causes of premature wear in total joint arthroplasty. For example, in retrieved UHMWPE tibial bearings, not only adhesive and abrasive wear, but also fatigue wear characterized by delamination and fracture is frequently observed. In this study, we examined the effects of gamma radiation on the microstructural morphology of UHMWPE tibial bearings, and propose a severe fatigue wear mechanism. Scanning electron microscopic observations were conducted on freeze\u2010fractured surface of retrieved UHMWPE components that had been sterilized with gamma radiation in air before implantation, unused components that had been stored on the shelf for several years (5\u201311) after sterilization, and disc specimens given an accelerated aging protocol after gamma radiation. Scanning electron microscopic observations showed that the freeze\u2010fractured surface of these components had a double layer, which was bordered below the surface. A closer observation of the subsurface layer below the border revealed an extremely rough and porous honeycomb\u2010like structure. Fourier transform infrared analysis demonstrated that the honeycomb\u2010like region in the subsurface had a high oxidation level. The internal morphology of oxidized UHMWPE was classified into four categories based on the level of the oxidation. According to these results, the morphological changes with oxidative degradation of gamma\u2010irradiated UHMWPEs in the presence of air could consistently be explained as the result of major chemical and physical changes such as increased crystallinity, elevated density, and reduced mechanical strength. We relate the morphological changes caused by oxidative degradation in the subsurface to the location of the origin of fatigue wear in total knee joints. \u00a9 2002 Wiley Periodicals, Inc. J Biomed Mater Res 62: 540\u2013549, 2002<\/jats:p>","DOI":"10.1002\/jbm.10357","type":"journal-article","created":{"date-parts":[[2002,10,8]],"date-time":"2002-10-08T22:45:48Z","timestamp":1034117148000},"page":"540-549","source":"Crossref","is-referenced-by-count":17,"title":["Oxidation\u2010induced dynamic changes in morphology reflected on freeze\u2010fractured surface of gamma\u2010irradiated ultra\u2010high molecular weight polyethylene components"],"prefix":"10.1002","volume":"62","author":[{"given":"Eiichiro","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Kaneeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitada","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Utsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideshige","family":"Moriya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,9,5]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199407000-00014"},{"key":"e_1_2_7_3_2","first-page":"232","article-title":"Analysis of the failure of 122 polyethylene inserts from uncemented tibial knee components","volume":"273","author":"Collier JP","year":"1996","journal-title":"Clin Orthop"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(95)00349-5"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0883-5403(98)90173-5"},{"key":"e_1_2_7_6_2","first-page":"28","article-title":"Impact of gamma sterilization on clinical performance of polyethylene in the hip","volume":"319","author":"Sutula LC","year":"1995","journal-title":"Clin Orthop"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0883-5403(96)80026-X"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199811000-00024"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199407000-00020"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100150109"},{"key":"e_1_2_7_11_2","first-page":"105","article-title":"Role of polyethylene oxidation and consolidation defects in cup performance","volume":"352","author":"Gomez\u2010Barrena E","year":"1998","journal-title":"Clin Orthop"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(98)00013-1"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199610000-00023"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199612000-00008"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199709000-00018"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(97)00160-9"},{"key":"e_1_2_7_17_2","first-page":"54","article-title":"Nonconsolidated polyethylene particles and oxidation in Charnley acetabular cups","volume":"319","author":"Li S","year":"1995","journal-title":"Clin Orthop"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(19981215)42:4<523::AID-JBM7>3.0.CO;2-1"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/pol.1983.180210404"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100150109"},{"issue":"2","key":"e_1_2_7_21_2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3928\/0147-7447-19970201-11","article-title":"Radiation\u2010induced physical changes in UHMWPE implant components","volume":"20","author":"Naidu SH","year":"1997","journal-title":"Orthopedics"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(96)82602-0"},{"key":"e_1_2_7_23_2","unstructured":"SanfordWM SaumKA.Accelerated oxidative aging testing of UHMWPE. 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