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In the <jats:italic>in vitro<\/jats:italic> experiments cages were subjected to aging up to 73 weeks in phosphate\u2010buffered solution (pH 7.4) at 37 \u00b0C. Inherent viscosity, crystallinity, and mechanical strength were determined at different time points. In the <jats:italic>in vivo<\/jats:italic> study, the poly\u2010L\u2010lactic acid cages were packed with bone graft and implanted in the L3\u2010L4 spinal motion segment of 18 Dutch milk goats. At 12, 26, and 52 weeks, the motion segments were isolated and poly\u2010L\u2010lactic acid samples retrieved. On evaluation, the <jats:italic>in vivo<\/jats:italic> implanted cages showed an advanced decline in inherent viscosity compared to the cages subjected to <jats:italic>in vitro<\/jats:italic> degradation experiments. At 6 months of implantation, the geometrical shape and original height of 10 mm was maintained during 6 months of follow up. This finding fits well with the observation that mechanical strength was maintained for a period of 6 months <jats:italic>in vitro<\/jats:italic>. At 12 months, the poly\u2010L\u2010lactic acid cage had been disintegrated into multiple fragments with signs of absorption. Despite the high\u2013load\u2010bearing conditions, the poly\u2010L\u2010lactic acid cage allowed interbody fusion to occur without collapse of the cage. \u00a9 2002 Wiley Periodicals, Inc. J Biomed Mater Res (Appl Biomater) 63: 752\u2013759, 2002<\/jats:p>","DOI":"10.1002\/jbm.10466","type":"journal-article","created":{"date-parts":[[2002,11,5]],"date-time":"2002-11-05T14:07:32Z","timestamp":1036505252000},"page":"752-759","source":"Crossref","is-referenced-by-count":69,"title":["<i>In vitro<\/i> and <i>in vivo<\/i> degradation of bioabsorbable PLLA spinal fusion cages"],"prefix":"10.1002","volume":"63","author":[{"given":"M.","family":"van Dijk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C.","family":"Tunc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. H.","family":"Smit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Higham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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