{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:58:23Z","timestamp":1762160303463},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,9,13]],"date-time":"2004-09-13T00:00:00Z","timestamp":1095033600000},"content-version":"vor","delay-in-days":8717,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Mater. Res."],"published-print":{"date-parts":[[1980,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In order to investigate whether the immune system is involved in the degradation of hydroxylapatite as implant material the adsorption behavior of several serum proteins to hydroxylapatite was studied and compared with the adsorption to other calcium phosphate compounds (Ca<jats:sub>3<\/jats:sub>(PO<jats:sub>4<\/jats:sub>)<jats:sub>2<\/jats:sub>, CaHPO<jats:sub>4<\/jats:sub>), calcium carbonate, aluminium oxide, and zinc oxide. It was found that complement factors, C<jats:sub>4<\/jats:sub> and C<jats:sub>3<\/jats:sub>, and \u03b1<jats:sub>2<\/jats:sub>\u2010HS\u2010glycoprotein adsorbed to the calcium phosphate compounds, but not to the other materials. IgG and albumin were adsorbed to all investigated compounds. These results suggest that the complement factors are directly adsorbed on the surface of the calcium phosphate compounds. Therefore, the activation of complement, if any, proceeds by the classical pathway. The binding of complement factors to the calcium phosphate salts investigated points to a more specific involvement of the immunosystem in the degradation process of calcium phosphate implants.<\/jats:p>","DOI":"10.1002\/jbm.820140602","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T12:19:08Z","timestamp":1104495548000},"page":"705-712","source":"Crossref","is-referenced-by-count":19,"title":["Interaction of some serum proteins with hydroxylapatite and other materials"],"prefix":"10.1002","volume":"14","author":[{"given":"C. P. A. T.","family":"Klein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"de Groot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P. W.","family":"Vermeiden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"van Kamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01261581"},{"key":"e_1_2_1_3_2","first-page":"93","article-title":"Tricalcium phosphate as a bone substitute","volume":"1","author":"Rejda B. V.","year":"1977","journal-title":"J. Bioeng."},{"key":"e_1_2_1_4_2","first-page":"79","article-title":"Tissue, cellular and subcellular events at a bone ceramic hydroxylapatite interface","volume":"1","author":"Jarcho M.","year":"1977","journal-title":"J. Bioeng."},{"key":"e_1_2_1_5_2","unstructured":"J. P. W.Vermeiden B. V.Rejda K.de Groot andJ. G. J.Peelen \u201cHistological evaluation of a porous Ca\u2010PO4bone replacement with good biocompatible properties \u201d Abstracts of the First European Conference \u201cEvaluation of Biomaterials \u201d Strassbourg 1977."},{"key":"e_1_2_1_6_2","first-page":"512","article-title":"Production of the complement cleavage product, C3a by activated macrophages and its tumarolytic effects","volume":"31","author":"Ferluga J.","year":"1978","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.32.100178.000315"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02010343"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820090407"},{"key":"e_1_2_1_10_2","volume-title":"Handbook of Physics","author":"Condon E. U.","year":"1967"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(65)90004-2"},{"key":"e_1_2_1_13_2","first-page":"747","article-title":"Complement as a mediator of inflammation in acute gouty arthritis. I. Studies on the reaction between human serum complement and sodium urate crystals","volume":"81","author":"Naff G. B.","year":"1973","journal-title":"J. Lab. Clin. Med."},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109360"},{"issue":"4","key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3109\/08820137409061113","article-title":"Opsonic properties of human serum alpha\u20102\u2010HS\u2010glycoprotein","volume":"3","author":"van Oss C. J.","year":"1974","journal-title":"Immun. Comm."}],"container-title":["Journal of Biomedical Materials Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.820140602","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.820140602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T12:07:06Z","timestamp":1699790826000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.820140602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,11]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1980,11]]}},"alternative-id":["10.1002\/jbm.820140602"],"URL":"https:\/\/doi.org\/10.1002\/jbm.820140602","archive":["Portico"],"relation":{},"ISSN":["0021-9304","1097-4636"],"issn-type":[{"value":"0021-9304","type":"print"},{"value":"1097-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,11]]}}}