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The hemoperfusion system developed here consists of a packed bed of a macroreticular resin which is made biocompatible by a coating of a monomolecular layer of albumin. The choice of the appropriate ionic form of the resin and the proper albumin coating and crosslinking procedure assures a high bilirubin adsorption capacity and excellent blood compatibility of the resin. The albumin coated resin removes <jats:italic>in vitro<\/jats:italic> 80\u201390% of the bilirubin initially present in the plasma. The results encourage <jats:italic>in vivo<\/jats:italic> clinical studies.<\/jats:p>","DOI":"10.1002\/jbm.820170109","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T12:37:28Z","timestamp":1104496648000},"page":"91-107","source":"Crossref","is-referenced-by-count":19,"title":["Preparation of a biocompatible albumin\u2010coated ion exchange resin for bilirubin removal from the blood of jaundiced newborns"],"prefix":"10.1002","volume":"17","author":[{"given":"S.","family":"Sideman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Mor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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