{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T23:37:01Z","timestamp":1770334621390,"version":"3.49.0"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,9,13]],"date-time":"2004-09-13T00:00:00Z","timestamp":1095033600000},"content-version":"vor","delay-in-days":7561,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Mater. Res."],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The application of agarose in hemoperfusion is hampered by the lack of a suitable sterilization method. A technique has been developed for the crosslinking of agarose encapsulated sorbents by the reaction with 1,3\u2010dichloro\u20102\u2010propanol (DCP) under strong alkaline conditions. A twofold molar excess of DCP with respect to agarose and an equimolar amount of sodium hydroxide at a concentration of 0.3 mol\/L with a reaction time of 1\u20134 h at 50\u00b0C are found to be the optimal conditions. The compressive strength of crosslinked beads is increased by a factor of 4. Agarose capsules are found to degrade by the influence of \u03b3 radiation, but are resistant to steam sterilization at 134\u00b0C during at least 30 min when crosslinked.<\/jats:p>","DOI":"10.1002\/jbm.820180103","type":"journal-article","created":{"date-parts":[[2004,12,28]],"date-time":"2004-12-28T20:11:43Z","timestamp":1104264703000},"page":"1-13","source":"Crossref","is-referenced-by-count":5,"title":["Crosslinked agarose encapsulated sorbents resistant to steam sterilization. Preparation and mechanical properties"],"prefix":"10.1002","volume":"18","author":[{"given":"Henk W. M.","family":"de Koning","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob A. F. M.","family":"Chamuleau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriaan","family":"Bantjes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107616"},{"key":"e_1_2_1_3_2","first-page":"59","article-title":"Eine neue Methode zur spezifischen Entfernung toxischer Substancen aus dem Blut","volume":"15","author":"Rawer P.","year":"1978","journal-title":"Intensivmed."},{"key":"e_1_2_1_4_2","volume-title":"Farmacia Fine Chemicals","year":"1979"},{"key":"e_1_2_1_5_2","first-page":"81","article-title":"Agarose encapsulated sorbents","volume":"2","author":"Holloway C. J.","year":"1979","journal-title":"Int. J. Artif. Organs"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3109\/10731197809118699","article-title":"Large agarose beads for extracorporeal detoxification systems","volume":"6","author":"Loesgen H.","year":"1978","journal-title":"Biomater. Med. Devices Artif. Organs"},{"key":"e_1_2_1_7_2","first-page":"37","volume-title":"Hemoperfusion","author":"Brunner G.","year":"1980"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/00337577508240804"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.1982.tb01673.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.1979.tb03797.x"},{"key":"e_1_2_1_11_2","unstructured":"T.Ouwerkerk \u201cGamma sterilization of medical plastics \u201d Proc. 3rd Int. Conf. Plastics in Medicine and Surgery PRI Enschede June 21\u201322 p.19.1\u201319.8(1979)."},{"key":"e_1_2_1_12_2","first-page":"2","volume-title":"Implants in Surgery","author":"Williams D. F.","year":"1973"}],"container-title":["Journal of Biomedical Materials Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.820180103","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.820180103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T05:50:14Z","timestamp":1697781014000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.820180103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1984,1]]}},"alternative-id":["10.1002\/jbm.820180103"],"URL":"https:\/\/doi.org\/10.1002\/jbm.820180103","archive":["Portico"],"relation":{},"ISSN":["0021-9304","1097-4636"],"issn-type":[{"value":"0021-9304","type":"print"},{"value":"1097-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,1]]}}}