{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:40:42Z","timestamp":1791304842007,"version":"4.3.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,9,13]],"date-time":"2004-09-13T00:00:00Z","timestamp":1095033600000},"content-version":"vor","delay-in-days":7561,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Mater. Res."],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An investigation into blood\u2010borne organometallic compounds that arise from the corrosion of metals used in orthopedic prosthetic devices was conducted using an <jats:italic>in vivo<\/jats:italic> rat model with an implantation time of 10 days and an <jats:italic>in vitro<\/jats:italic> human serum model with an incubation time of 5 days. Both models involved 316LSS and HS\u201021<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#note1\"\/><jats:fn><jats:p>Haynes Stellite 21: Stellite Division of Cobalt Corporation, Kokomo, Indiana (An alloy of very similar composition to ASTM F\u201075)<\/jats:p><\/jats:fn>\n in the spherical powder form of 55 \u00b1 5 \u03bcm microns in diameter at three different surface areas to body weight ratios. Gel chromatography on cross\u2010linked dextran (G\u2010200) was used to fractionate the serum proteins which bound the metal ions (chromium, cobalt, and nickel) released and identify them. Atomic\u2010absorption\u2010spectrophotometry analysis measured the concentration of the metal ions in each serum protein peak as well as whole serum from both models, and red cell and tissue from the <jats:italic>in vivo<\/jats:italic> model. Within the serum proteins, the metal ions were bound to two of the principal serum protein peaks. Similar distributions of the metals among the serum protein peaks were not noted.<\/jats:p>","DOI":"10.1002\/jbm.820180110","type":"journal-article","created":{"date-parts":[[2004,12,28]],"date-time":"2004-12-28T20:11:43Z","timestamp":1104264703000},"page":"99-114","source":"Crossref","is-referenced-by-count":80,"title":["Isolation of serum protein organometallic corrosion products from 316LSS and HS\u201021 <i>in vitro<\/i> and <i>in vivo<\/i>"],"prefix":"10.1002","volume":"18","author":[{"given":"J. L.","family":"Woodman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. A.","family":"Jiminez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,9,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-196042010-00007"},{"key":"e_1_2_1_3_2","first-page":"345","article-title":"Corrosion of Surgical Implants","volume":"1","author":"Greene N. D.","year":"1966","journal-title":"J. Mater."},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1302\/0301-620X.48B3.567","article-title":"Electron Probe Microanalysis of Tissue and Cells from Implant Areas","volume":"48","author":"Mears D. C.","year":"1966","journal-title":"J. Bone Jt. Surg."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820040204"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820080609"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820030205"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02518564"},{"key":"e_1_2_1_9_2","unstructured":"G. K.SmithandJ.Black \u201cModels for Systemic Effects of Metallic Implants \u201d Retrieval and Analysis of Orthopaedic Implants: Proc. of Symp. at Ntl. Bur. of Stand. Gaithersburg MD. March 5 1976."},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820080304"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820070409"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3233(08)60424-6"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00872a006"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00814a005"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1093\/clinchem\/18.12.1478","article-title":"63Ni Complexes in Rabbit Serum and Urine after Injection of 63NiCl2","volume":"18","author":"Van Soestbergen M.","year":"1972","journal-title":"Clin. Chem. N.Y."},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00785a023"},{"key":"e_1_2_1_17_2","volume-title":"Clinical Chemistry and Chemical Toxicology of Me","author":"Onkelinx C.","year":"1977"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"547","DOI":"10.2106\/00004623-196850030-00014","article-title":"Toxicity of Metal Particles in Tissue Culture. Part II: A New Assay Method Using Cell Counts in the Lag Phase","volume":"50","author":"Mital M.","year":"1968","journal-title":"J. Bone Jt. Surg."},{"key":"e_1_2_1_19_2","unstructured":"ASTM Standard For Stainless Steel Bar and Wire For Surgical Implants Annual Book of ASTM Standards Sfication F55\u201382 Part 46 1982 pp.481\u2013482."},{"key":"e_1_2_1_20_2","unstructured":"ASTM Standard For Cast Cobalt\u2010Chromium Molybdenum Alloy For Surgical Implant Applications Annual Book Of ASTM StandardsSpecification F75\u201376 Part 46 1982 pp.491\u2013492."},{"key":"e_1_2_1_21_2","unstructured":"ASTM Standard Recommended Practice For Surface Preparation and Marking of Metallic Surgical Implants Annual Book of ASTM Standard Specification F86\u201376 Part 46 1982 pp.493\u2013494."},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3002(62)90104-X"},{"key":"e_1_2_1_23_2","unstructured":"J. L.Woodman \u201cOrganometallic Corrosion Products: AnIn VivoandIn VitroComparison \u201d Ph.D. Dissertation University of Pennsylvania 1980 unpublished."},{"key":"e_1_2_1_24_2","volume-title":"The Plasma Proteins","author":"Putnam F. W.","year":"1975"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_26_2","volume-title":"Analytical Methods For Furnace Atomic Absorption Spectroscopy","year":"1979"},{"key":"e_1_2_1_27_2","first-page":"166","article-title":"Corrosion Release of Cobalt and Nickel from a New Total Finger Joint Prosthesis Made of Vitallium","volume":"6","author":"Woodman J. 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