{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:50:17Z","timestamp":1777553417614,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,9,13]],"date-time":"2004-09-13T00:00:00Z","timestamp":1095033600000},"content-version":"vor","delay-in-days":6222,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Mater. Res."],"published-print":{"date-parts":[[1987,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A blinded study was designed to provide qualitative and quantitative evaluation on the possible therapeutic benefits of the use of Pluronic\u00ae Polyol F\u2010127 as a substitute skin in standardized third\u2010degree thermal burns. Three separate burns, approximately 1600 mm<jats:sup>2<\/jats:sup>, were induced on the shaved backs of young, anesthetized pigs. Each animal served as its own control. One burn site was left untreated while the other two sites were covered with coded preparations of the Pluronic\u00ae F\u2010127 gel with additives. Polaroid photographs with a fixed focal\u2010length camera were taken of all burn sites for planimetry analysis. Biopsies taken confirmed that third\u2010degree burns were achieved. The pigs were followed for 30 days. The rate of healing of third\u2010degree thermal burns was significantly accelerated over control sites when treated with Pluronic\u00ae Polyol F\u2010127 plus propylene glycol. When the bacteriostatic agent Garamycin was also added, the rate of healing remained significantly better than untreated controls. With the addition of Piracetam, burn wound healing was actually retarded within 30 days, when applied topically. Thus, wound healing was both accelerated and retarded as a function of the particular Pluronic\u00ae preparation used to treat specific burn sites. This experimental modulation of wound healing suggests that the non\u2010ionic poloxamer, Pluronic F\u2010127, can significantly enhance the rate of wound healing by some unknown mechanism, possibly by stimulation of epithelial growth factor (EGF).<\/jats:p>","DOI":"10.1002\/jbm.820210907","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T12:53:54Z","timestamp":1104497634000},"page":"1135-1148","source":"Crossref","is-referenced-by-count":82,"title":["Pluronic F\u2010127 gel preparation as an artificial skin in the treatment of third\u2010degree burns in pigs"],"prefix":"10.1002","volume":"21","author":[{"given":"Robert M.","family":"Nalbandian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond L.","family":"Henry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth W.","family":"Balko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis V.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norwood R.","family":"Neuman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,13]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"G. H.Tryon Fire Protection Handbook 12th Edition 1962."},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1978.01370160055007"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-198303000-00002"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198511283132205"},{"key":"e_1_2_1_6_2","first-page":"1","volume-title":"Burn Wound Coverings","author":"de Reil S.","year":"1984"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/10731197809118690"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/02844317909013019"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-136-35427"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1979.tb00678.x"},{"key":"e_1_2_1_11_2","first-page":"335A","article-title":"Fibronectin: A tissue matrix protein associated with fibroblast, epithelial cell and endothelial cell migation during wound healing","volume":"76","author":"Clark R. A. F.","year":"1981","journal-title":"J. Invest. Dermatol."},{"key":"e_1_2_1_12_2","first-page":"838","article-title":"Studies in burns. XV. Use of topical liquid in treating human burns","volume":"42","author":"Jelenko C.","year":"1976","journal-title":"Am. Surg."},{"key":"e_1_2_1_13_2","first-page":"615","volume-title":"Histology","author":"Ham A. W.","year":"1965"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820060609"},{"key":"e_1_2_1_15_2","first-page":"59","volume-title":"Biostatics. An Introductory Text","author":"Goldstein A.","year":"1965"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820060610"},{"key":"e_1_2_1_17_2","unstructured":"J. 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M.Nalbandian andH.Balko Unpublished data."},{"key":"e_1_2_1_26_2","first-page":"4751\u2010B","article-title":"Drug release from Pluronic* F\u2010127 gels","volume":"40","author":"Chen\u2010Chow P.","year":"1979","journal-title":"Diss. Abs. Intl."},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5173(81)90013-2"},{"key":"e_1_2_1_28_2","first-page":"239","article-title":"Drug release from Pluronic* F\u2010127 gels","volume":"18","author":"Chen\u2010Chow P.","year":"1981","journal-title":"Acta Pharm. 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