{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:34:54Z","timestamp":1772253294833,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,9,13]],"date-time":"2004-09-13T00:00:00Z","timestamp":1095033600000},"content-version":"vor","delay-in-days":5126,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Mater. Res."],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A new canine model utilizing an implantable chamber with multiple bone in\u2010growth channels has been used to study the response of intramedullary bone to various implant materials and surfaces.<\/jats:p><jats:p>The first group of dogs received implants containing channels lined by smooth\u2010surfaced coupons of titanium, titanium alloy, sputter\u2010hydroxyapatite\u2010coated (HA\u2010coated) titanium alloy, and polyethylene. A pattern of early initial bone ingrowth by 2 weeks, becoming maximal at 6 to 12 weeks with remodeling to a more mature lamellar bone, and later resorption by 24 weeks was seen for all test groups, with fibrous tissue interfaces covering the smooth test coupons at all time points. Significantly increased bone ingrowth in the sputter\u2010HA coated group was found only at 6 weeks.<\/jats:p><jats:p>The second group of dogs received implants with channels lined by surfaceroughened coupons of either titanium or plasma\u2010HA\u2010coated titanium, half of which were also packed with a crystalline\u2010HA grouting at the time of surgery. At both 6 and 12 weeks, bone ingrowth was greatly enhanced by the presence of the plasma\u2010HA coating or the crystalline\u2010HA grouting as compared to the uncoated titanium channels. Histologically, bone was seen to bond directly to the plasma\u2010HA coating and the crystalline\u2010HA grouting. A thin fibrous tissue layer was noted between bone and the titanium in most areas, but evidence of direct bone contact to the metal surface was seen. Mechanical testing in tension of intact coupon\u2010\u2010bone\u2010\u2010coupon units revealed significant strength of the bone\u2010\u2010plasma\u2010\u2010HA bond, with failure initiating at the metal\u2010HA interface with forces of 15.3 N at 6 weeks, increasing to 44.8 N at 12 weeks. Plasma\u2010HA\u2010lined channels with crystalline\u2010HA packing required similar forces for failure. No significant adhesion strength was noted for the titanium channels at 6 weeks, and only the crystalline\u2010HA\u2010filled channels displayed measurable strength of the bone\u2010\u2010titanium interface at 12 weeks, with a force of 9 N needed for failure.<\/jats:p>","DOI":"10.1002\/jbm.820240902","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T13:09:52Z","timestamp":1104498592000},"page":"1121-1149","source":"Crossref","is-referenced-by-count":98,"title":["A new canine model to evaluate the biological response of intramedullary bone to implant materials and surfaces"],"prefix":"10.1002","volume":"24","author":[{"given":"Jeffrey M.","family":"Spivak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L.","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman C.","family":"Blumenthal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.2106\/00004623-198769090-00026","article-title":"Biological fixation of porous\u2010coated implants","volume":"69","author":"Haddad R. J.","year":"1987","journal-title":"J. Bone Jt. Surg."},{"key":"e_1_2_1_3_2","first-page":"147","article-title":"Chemical implant fixation using hydroxyl\u2010apatite coatings","volume":"225","author":"Geesink R. G. T.","year":"1987","journal-title":"Clin. Orthop. Rel. Res."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1988.tb38502.x"},{"key":"e_1_2_1_5_2","unstructured":"J. A.Longo F. P.Magee S. E.Mather R. A.Yapp J. B.Koeneman andA. M.Weinstein \u201cComparison of HA and non\u2010HA coated carbon composite femoral stems \u201d Transactions of the 35th Annual Meeting of the Orthopaedic Research Society Las Vegas Nevada 384 1989."},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820200107"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/00003086-198401000-00033","article-title":"An evaluation of skeletal attachment of LTI pyrolytic carbon, porous titanium, and carbon\u2010coated porous titanium implants","volume":"182","author":"Anderson R. C.","year":"1984","journal-title":"Clin. Orthop. Rel. Res."},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1302\/0301-620X.70B1.2828374","article-title":"Bonding of bone to apatite\u2010coated implants","volume":"70","author":"Geesink R. G. T.","year":"1988","journal-title":"J. Bone Jt. Surg."},{"key":"e_1_2_1_9_2","first-page":"225","article-title":"Hydroxyapatitecoated titanium for orthopedic implant applications","volume":"232","author":"Cook S. D.","year":"1988","journal-title":"Clin. Orthop. Rel. Res."},{"key":"e_1_2_1_10_2","first-page":"303","article-title":"Hydroxyapatitecoated porous titanium for use as an orthopedic biologic attachment system","volume":"230","author":"Cook S. D.","year":"1988","journal-title":"Clin. Orthop. Rel. Res."},{"key":"e_1_2_1_11_2","volume-title":"Bioceramics of Calcium Phophate","author":"Driessens F. C. M.","year":"1983"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198106000-00037"},{"key":"e_1_2_1_13_2","first-page":"79","article-title":"Tissue cellular and subcellular events at a bone\u2010ceramic hydroxyapatite interface","volume":"1","author":"Jarcho M.","year":"1977","journal-title":"J. Bioeng."},{"issue":"2","key":"e_1_2_1_14_2","first-page":"103","article-title":"Evaluation of bonding of bone to inorganic crystal surfaces","volume":"43","author":"Walker M. M.","year":"1983","journal-title":"Bull. Hosp. Joint Dis. Orthop. Inst."},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820140305"},{"key":"e_1_2_1_16_2","first-page":"477","volume-title":"Biological and Biomechanical Performance of Biomaterials","author":"Parsons J. R.","year":"1986"},{"key":"e_1_2_1_17_2","first-page":"25","article-title":"Implantable devices for long\u2010term vital microscopy of bone tissue","volume":"3","author":"Albrektsson T.","year":"1987","journal-title":"Crit. Rev. Biocompat."},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100060409"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(88)90022-1"},{"key":"e_1_2_1_20_2","unstructured":"J. J.Benedict A. B.Prewett M. N.Kern W. C.Fox T. B.Aufdemorte andJ. W.Posner \u201cThe evaluation in primates of a bovine derived osteogenic factor using the analytical bone implant model \u201d Transactions of the 15th Annual Meeting of the Society for Biomaterials Lake Buena Vista FL 125 1989."},{"key":"e_1_2_1_21_2","unstructured":"T.AlbrektssonandL.Linder \u201cA method for in vivo observations of the current\u2010bone interface \u201d Proceedings of the 1st World Congress on Biomaterials Austria 140 1980."},{"key":"e_1_2_1_22_2","unstructured":"H.Winet J. Y.Bao andR.Moffat \u201cControl\u2010control bone chamber model for quantitative evaluation of cortical bone primary healing \u201d Transactions of the 35 Annual Meeting of the Orthopaedic Research Society Las Vegas NV 563 1989."},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820100411"},{"key":"e_1_2_1_24_2","volume-title":"Biocompatibility of Clinical Implant Materials","author":"Williams D. F.","year":"1981"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453678108991776"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453678308992868"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(85)90070-5"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(86)90103-1"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0141-5425(89)90158-1"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820231305"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198007000-00045"},{"key":"e_1_2_1_32_2","first-page":"271","article-title":"Interface mechanics and bone growth into porous co\u2010cr\u2010mo alloy implants","volume":"193","author":"Cook S. J.","year":"1985","journal-title":"Clin. Orthop. Rel. Res."},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820190802"},{"key":"e_1_2_1_34_2","unstructured":"F. P.Magee J. A.Longo andA. K.Hedley \u201cThe effect of age on the interface strength between porous coated implants and bone \u201d Transcripts of the 35th Annual Meeting of the Orthopaedic Research Society Las Vegas NV 575 1989."},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820211205"},{"key":"e_1_2_1_36_2","unstructured":"P. C.Noble J. W.Alexander J. A.Maltry D. T.Yew andH. S.Tullos \u201cThe myth of a press\u2010fit cementless femoral prosthesis \u201d Presented at the 55th Annual Meeting Amer. Acad. Orthp. Surg. Atlanta Feb. 4\u20139 1988."},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820231102"},{"key":"e_1_2_1_38_2","unstructured":"K.S\u00f8balle E. S.Hansen H.B\u2010Rasmussen G. I.Juhl C. M.Pedersen V.Knudsen I.Hvid andC.B\u00fcnger \u201cEnhancement of osteopenic and normal bone ingrowth into porous coated implants by hydroxyapatite coating \u201d Transcripts of the 35th Annual Meeting of the Orthopaedic Research Society Las Vegas NV 554 1989."},{"key":"e_1_2_1_39_2","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1302\/0301-620X.70B4.3403596","article-title":"Clinical aspects of osteointegration in joint replacement: a histologic study of titanium implants","volume":"70","author":"Linder L.","year":"1988","journal-title":"J. Bone Jt. Surg."}],"container-title":["Journal of Biomedical Materials Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.820240902","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.820240902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T16:29:44Z","timestamp":1697992184000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.820240902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,9]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1990,9]]}},"alternative-id":["10.1002\/jbm.820240902"],"URL":"https:\/\/doi.org\/10.1002\/jbm.820240902","archive":["Portico"],"relation":{},"ISSN":["0021-9304","1097-4636"],"issn-type":[{"value":"0021-9304","type":"print"},{"value":"1097-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,9]]}}}