{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:15:13Z","timestamp":1759331713020},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,9,13]],"date-time":"2004-09-13T00:00:00Z","timestamp":1095033600000},"content-version":"vor","delay-in-days":4884,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Mater. Res."],"published-print":{"date-parts":[[1991,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present study was designed to ascertain if dynamic ionic matrices that mimic the mineralization front could be used as active scaffolds for bone repair. Dentinal phosphophoryn calcium salts were extracted from unerupted bovine dentin using chatopic buffers and EDTA. The phosphophoryns were subsequently isolated following precipitation with CaCl<jats:sub>2<\/jats:sub>. The phosphophoryn\u2010Ca<jats:sup>+2<\/jats:sup> salts were then mixed with pepsin solubilized bovine skin collagen and lyophilized into hardened sponges. Three groups of 4 beagle dogs were employed such that one leg served as an experimental test site for a mechanical wound, while the contralateral leg served as a control. Animals were sacrificed at 1, 3, and 6 month intervals. The test specimens were harvested, fixed, and processed for routine histology, examined with image histomorphometric analysis, and scored. Tabulation of these data indicated that phosphophoryn\u2010Ca<jats:sup>+2<\/jats:sup>\u2010collagen enhances the repair of mechanically formed osseous defects in the distal femur of beagle dogs. This enhanced rate of bone repair was manifest by earlier filling of bony voids with osteoid and trabecular bone. Eventually, this process was followed by recortification of the surface defects. These data suggest that components derived from a mineralization front may influence bone formation in unicortical defects within long bones.<\/jats:p>","DOI":"10.1002\/jbm.820250505","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T12:07:03Z","timestamp":1104494823000},"page":"609-619","source":"Crossref","is-referenced-by-count":5,"title":["Use of a phosphophoryn\u2010Ca<sup>+2<\/sup>\u2010collagen composition that mimics a mineralization front in unicortical defects in long bones"],"prefix":"10.1002","volume":"25","author":[{"given":"John J.","family":"Sauk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig L.","family":"Van Kampen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.11.3419"},{"key":"e_1_2_1_3_2","first-page":"88","article-title":"Bone histogenesis and morphogenesis in implants of demineralized enamel and dentin","volume":"29","author":"Urist M. R.","year":"1971","journal-title":"J. Oral Surg."},{"key":"e_1_2_1_4_2","volume-title":"The Chemistry and Biology of Mineralized Tissues","author":"Butler W. T.","year":"1985"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/00003086-198106000-00037","article-title":"Calcium phosphate ceramics as hard tissue prosthetics","volume":"157","author":"Jarcho M. M.","year":"1981","journal-title":"Clin. Orthop. Related Res."},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/00003086-198606000-00046","article-title":"Biodegradable bone repair materials: Synthetic polymers and ceramics","volume":"207","author":"Hollinger J. O.","year":"1986","journal-title":"Clin. Ortho. Related Res."},{"key":"e_1_2_1_7_2","first-page":"170","volume-title":"The Chemistry and Biology of Mineralized Tissues","author":"Veis A.","year":"1985"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345790580092001"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820230103"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(80)90059-9"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-196909000-00025"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345770560030701"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/10826068009412827"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"9769","DOI":"10.1016\/S0021-9258(18)43459-X","article-title":"Properties of dissociatively extracted fetal tooth matrix proteins II. Separation and purification of fetal bovine dentin","volume":"225","author":"Termine J. D.","year":"1980","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02411214"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(83)90021-8"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0174-173X(81)80019-2"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02405323"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00287a025"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02405327"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)92338-0"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00632a026"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1981.tb05096.x"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00661a008"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-7944-4_25"},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/00003086-198407000-00042","article-title":"Beta\u2010tricalcium phosphate delivery system for bone morphogenetic protein","volume":"187","author":"Urist M. R.","year":"1984","journal-title":"Clin. Ortho. Related Res."},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650050708"}],"container-title":["Journal of Biomedical Materials Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.820250505","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.820250505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T05:58:41Z","timestamp":1698040721000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.820250505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,5]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1991,5]]}},"alternative-id":["10.1002\/jbm.820250505"],"URL":"https:\/\/doi.org\/10.1002\/jbm.820250505","archive":["Portico"],"relation":{},"ISSN":["0021-9304","1097-4636"],"issn-type":[{"value":"0021-9304","type":"print"},{"value":"1097-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,5]]}}}