{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:48:19Z","timestamp":1791265699772,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,9,13]],"date-time":"2004-09-13T00:00:00Z","timestamp":1095033600000},"content-version":"vor","delay-in-days":4061,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Mater. Res."],"published-print":{"date-parts":[[1993,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two assays were carried out to investigate the postulates that dissolution\/reprecipitation phenomena and epitaxis are involved in the formation of the bond between sintered hydroxyapatite (HA) and bone. HA was exposed to a physiologic solution and the ions going into solution quantified using inductively coupled plasma (ICP) emission spectroscopy. The HA was retrieved and examined using scanning electron microscopy (SEM). In the second assay, HA was implanted into Alsatian femura. Following retrieval, specimens were prepared and studied with SEM, at magnifications usually reserved for transmission electron microscopy (TEM). <jats:italic>In vitro<\/jats:italic> the HA surface composition appeared to shift to the acidic (calcium\u2010deficient) direction. The HA surfaces in both assays underwent a dissolution\/reprecipitation degradation of varying severity, forming a recrystallization layer of spherocrystallites. Two modes of bone bonding to implanted HA were identified: (1) bone tissue components bonded to HA via a recrystallization zone similar in structure to the reprecipitation layer in the corrosion assay, and (2) bone tissue components bonded directly to HA crystals with no morphologically discernible signs of dissolution embarrassment. The formation of the bone\/HA bond seems to involve dissolution\/reprecipitation phenomena. What is believed to be the first morphological evidence of epitaxial growth involvement in the formation of this bond is presented. \u00a9 1993 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/jbm.820270810","type":"journal-article","created":{"date-parts":[[2005,5,27]],"date-time":"2005-05-27T19:29:42Z","timestamp":1117222182000},"page":"1047-1055","source":"Crossref","is-referenced-by-count":167,"title":["Mechanisms and structure of the bond between bone and hydroxyapatite ceramics"],"prefix":"10.1002","volume":"27","author":[{"given":"Frank B.","family":"Bagambisa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Joos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Schilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,9,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820050611"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820070304"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820080307"},{"key":"e_1_2_1_5_2","first-page":"59","volume-title":"Advances in Biomaterials, Vol. 3: Biomaterials 1980","author":"Ogiso M.","year":"1982"},{"key":"e_1_2_1_6_2","first-page":"217","article-title":"The interaction of osteogenic cells with hydroxylapatite implant materials in vitro and in vivo","volume":"5","author":"Bagambisa F. B.","year":"1990","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198106000-00037"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820251010"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00580134"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820260203"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345840630120201"},{"key":"e_1_2_1_12_2","first-page":"79","article-title":"Tissue, cellular, and subcellular events at a bone\u2010ceramic hydroxyapatite interface","volume":"1","author":"Jarcho M.","year":"1977","journal-title":"J. Bioeng."},{"key":"e_1_2_1_13_2","unstructured":"J. F.Kay R. H.Doremus andM.Jarcho \u201cIon micromilling of bone\u2010implant interfaces \u201dTrans. 4th Ann. Meet. Soc. Biomater. 10th Int. Biomater. Symp. pp.154\u2013155(1978)."},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820140603"},{"key":"e_1_2_1_15_2","volume-title":"Metals and Engineering in Bone and Joint Surgery","author":"Bechtol C. O.","year":"1959"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2389.1979.tb00982.x"},{"key":"e_1_2_1_17_2","first-page":"49","volume-title":"Bioceramics in Medicine","author":"Bagambisa F. B.","year":"1990"},{"key":"e_1_2_1_18_2","unstructured":"T.Ichijo T.Hidaka andI.Furuta \u201cComparative study to the ultrastructure of synthetic hydroxyapatite crystals and human tooth and bone crystals \u201dTransactions of the Fourth World Biomaterials Congress April 24\u201328 1992 Berlin Germany p.211."},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-81835-6"},{"key":"e_1_2_1_20_2","volume-title":"Handbook on Semiconductors, Vol. III, Materials, Properties, and Preparations","author":"Moss T. 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