{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T11:35:19Z","timestamp":1789817719861,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,9,13]],"date-time":"2004-09-13T00:00:00Z","timestamp":1095033600000},"content-version":"vor","delay-in-days":3849,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Mater. Res."],"published-print":{"date-parts":[[1994,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The biocompatibility and tissue regenerating capacity of four crosslinked dermal sheep collagens (DSC) was studied. <jats:italic>In vitro<\/jats:italic>, the four DSC versions were found to be noncytotoxic or very low in cytoxicity. After subcutaneous implantation in rats, hexamethylenediisocyanatecrcrosslinked DSC (HDSC) seldom induced an increased infiltration of neutrophils or macrophages, as compared with normal wound healing; whereas new formation of collagen was observed. DSC crosslinked with glutaraldehyde (GDSC) followed by reaction with NaBH<jats:sub>4<\/jats:sub> shortly after implantation showed an increased infiltration of neutrophils with a deviant morphology. Furthermore, a high incidence of calcification was observed, which may explain the minor ingrowth of giant cells and fibroblasts, and the poor formation of new rat collagen. Acyl azide\u2010crosslinked DSC (AaDSC) first induced an increased infiltration of macrophages, and then of giant cells, both with high lipid formation. AaDSC degraded at least twice as slowly as HDSC and GDSC, finally leaving a matrix of newly formed rat collagen. Samples crosslinked with 1\u2010ethyl\u20103\u2010(3\u2010dimethylaminopropyl)carbodiimide hydrochloride and <jats:italic>N<\/jats:italic>\u2010hydroxysuccinimide (ENDSC) induced the same mild cellular reaction as HDSC; whereas, similar to AaDSC, the degradation rate was slow and an optimal rat collagen matrix was formed. Of the crosslinked DSC samples, ENDSC seems most promising for tissue regeneration. \u00a9 1994 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/jbm.820280310","type":"journal-article","created":{"date-parts":[[2004,12,28]],"date-time":"2004-12-28T20:14:35Z","timestamp":1104264875000},"page":"353-363","source":"Crossref","is-referenced-by-count":188,"title":["Biocompatibility and tissue regenerating capacity of crosslinked dermal sheep collagen"],"prefix":"10.1002","volume":"28","author":[{"given":"P. B.","family":"van Wachem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J. A.","family":"van Luyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. H. H. Olde","family":"Damink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J.","family":"Dijkstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Feijen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Nieuwenhuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,9,13]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"61","volume-title":"Implant Materials in Biofunction","author":"van der Wal A. C.","year":"1988"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1177\/039139889101401010","article-title":"Dermal sheep collagen for the repair of abdominal wall defects","volume":"14","author":"van der Laan J. S.","year":"1991","journal-title":"Int. J. Artif. Organs"},{"key":"e_1_2_1_4_2","first-page":"1183","article-title":"Achilles tendon replacement by a collagen fiber prosthesis: Morphological evaluation of neotendon formation","volume":"3","author":"Wasserman A. J.","year":"1989","journal-title":"Scanning Microsc."},{"issue":"1","key":"e_1_2_1_5_2","first-page":"30","article-title":"The use of high\u2010grade processed dermal sheep collagen in cruciate ligament substitution","volume":"19","author":"Steinberg P. J.","year":"1987","journal-title":"Eur. Surg. Res."},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/00003086-198811000-00037","article-title":"Evaluation of Dacron\u2010covered and plain bovine xenografts as replacements for the anterior cruciate ligament","volume":"236","author":"Berry J. L.","year":"1988","journal-title":"Clin. Orthop. Rel. Res."},{"key":"e_1_2_1_7_2","first-page":"69","article-title":"Processed dermal sheep collagen as a small diameter vascular graft","volume":"19","author":"Bannenberg J. J. G.","year":"1987","journal-title":"Eur. Surg. Res."},{"key":"e_1_2_1_8_2","first-page":"107","article-title":"Structural stability of long\u2010term implants of a collagen\u2010based vascular prosthesis","volume":"1","author":"Werkmeister J. A.","year":"1991","journal-title":"J. Long\u2010term Effects Medical Implants"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820240605"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(90)90125-A"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(90)90148-J"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00692972"},{"key":"e_1_2_1_13_2","unstructured":"M. J. A.van Luyn P. B.van Wachem L. OldeDamink J.Feijen andP.Nieuwenhuis \u201cEnzymepretreatment removes cytotoxic effects of dermal sheep collagen \u201d inTissue Inducing Biomaterials Linda G. Cima and Eyal Ron eds. 1992 pp.167\u2013174."},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820260810"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(92)90153-F"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(91)90203-M"},{"key":"e_1_2_1_17_2","first-page":"251","article-title":"Tissue interactions with dermal sheep collagen implants: A transmission electron microscopical evaluation","volume":"1","author":"van Wachem P. B.","year":"1991","journal-title":"Cell Materials"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","unstructured":"P. B.van Wachem M. J. A.van Luyn L. H. H. OldeDamink P. J.Dijkstra J.Feijen andP.Nieuwenhuis \u201cIn vivo interactions with (tissue culture pretreated) dermal sheep collagen \u201d inTissue Inducing Biomaterials Linda G. Cima and Eyal Ron eds. 1992 pp.117\u2013124.","DOI":"10.1557\/PROC-252-117"},{"key":"e_1_2_1_19_2","unstructured":"L. H. H. OldeDamink P. J.Dijkstra M. J. A.van Luyn P. B.van Wachem P.Nieuwenhuis andJ.Feijen \u201cIn vitro comparison of collagen crosslinking methods \u201d abstract Fourth World Biomaterials Congress Berlin FRG April 24\u201328 1992 p.45."},{"key":"e_1_2_1_20_2","unstructured":"L. H. H. OldeDamink P. J.Dijkstra M. J. A.van Luyn P. B.van Wachem P.Nieuwenhuis andJ.Feijen \u201cCrosslinking of dermal sheep collagen using hexamethylene diisocyanate \u201d in preparation"},{"key":"e_1_2_1_21_2","unstructured":"L. H. H. OldeDamink P. J.Dijkstra M. J. A.van Luyn P. B.van Wachem P.Nieuwenhuis andJ.Feijen \u201cGlutaraldehyde as a crosslinking agent for collagen\u2010based biomaterials \u201d in preparation."},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820240205"},{"key":"e_1_2_1_23_2","unstructured":"L. H. H. OldDamink P. J.Dijkstra M. J. A.van Luyn P. B.van Wachem P.Nieuwenhuis andJ.Feijen \u201cCrosslinking of dermal sheep collagen using a water soluble carbodiimide \u201d in preparation."},{"key":"e_1_2_1_24_2","first-page":"90","article-title":"The processing of sheepskin for use as a dermal collagen graft\u2014an experimental study","volume":"39","author":"van Gulik T. M.","year":"1987","journal-title":"Neth. J. Surg."},{"key":"e_1_2_1_25_2","unstructured":"L. H. H. OldeDamink H.ten Hoopen P. J.Dijkstra M. J. A.van Luyn P. B.van Wachem P.Nieuwenhuis andJ.Feijen \u201cChanges in the mechanical properties of dermal sheep collagen during in vitro degradation \u201d in preparation."},{"key":"e_1_2_1_26_2","unstructured":"L. H. H. OldeDamink P. J.Dijkstra M. J. A.van Luyn P. B.van Wachem P.Nieuwenhuis andJ.Feijen \u201cIn vitro degradation of dermal sheep collagen crosslinked using carboxylic acid activating methods \u201d in preparation."},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01551a020"},{"key":"e_1_2_1_28_2","unstructured":"L. H. H. OldeDamink P. J.Dijkstra M. J. A.van Luyn P. B.van Wachem P.Nieuwenhuis andJ.Feijen \u201cInfluence of ethylene oxide gas treatment on the in vitro degradation of dermal sheep collagen \u201d in preparation."},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(89)90079-3"},{"key":"e_1_2_1_30_2","first-page":"54","article-title":"Isolierung und teilweise Charakterisierung von Schafshautkollagen, in L\u00f6sung gebracht mit Hilfe von Subtilisin DY","volume":"34","author":"Nedkov P.","year":"1983","journal-title":"Leder"},{"key":"e_1_2_1_31_2","volume-title":"Living Blood Cells and Their Ultrastructure","author":"Bessis M.","year":"1973"},{"key":"e_1_2_1_32_2","first-page":"5","article-title":"Biology of disease: New insights into 'the riddle of mast cells': Microenvironmental regulation of mast cell development and phenotypic heterogeneity","volume":"62","author":"Galli S. J.","year":"1990","journal-title":"Lab. Invest."},{"key":"e_1_2_1_33_2","first-page":"157","volume-title":"Cell and Tissue Biology and Textbook of Histology","author":"Weiss L.","year":"1988"},{"key":"e_1_2_1_34_2","first-page":"71","article-title":"Calcification of subcutaneously implanted type I collagen sponges: Effects of formaldehyde and glutaraldehyde pretreatments","volume":"122","author":"Levy R. J.","year":"1986","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_35_2","first-page":"11","article-title":"Biomaterial\u2010associated calcification: Pathology, mechanisms, and strategies for prevention","volume":"22","author":"Schoen F. J.","year":"1988","journal-title":"J. Biomed. Mater. Res. Appl. Biomater."},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820140607"},{"key":"e_1_2_1_37_2","unstructured":"M. J. A.van Luyn P. B.van Wachem L. H. H. OldeDamink P. J.Dijkstra J.Feijen andP.Nieuwenhuis \u201cCalcification of crosslinked collagens after subcutaneous implantation \u201d abstract Transactions of the 19th Annual Meeting of the Society for Biomaterials Birmingham AL April 28\u2013May 2 1993 p.28."},{"key":"e_1_2_1_38_2","doi-asserted-by":"crossref","unstructured":"P. B.van Wachem M. J. A.van Luyn H. K.Koerten L. OldeDamink H.ten Hoopen J.Feijen andP.Nieuwenhuis \u201cTissue regenerating capacity of carbodiimide\u2010crosslinked dermal sheep collagen during repair of the abdominal wall \u201d abstract 4th Int. Conf. BioInteractions '93 Noordwijkerhout The Netherlands August 29\u2013September 1 1993 p.59.","DOI":"10.1177\/039139889401700407"}],"container-title":["Journal of Biomedical Materials Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.820280310","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.820280310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T15:15:55Z","timestamp":1695827755000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.820280310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,3]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,3]]}},"alternative-id":["10.1002\/jbm.820280310"],"URL":"https:\/\/doi.org\/10.1002\/jbm.820280310","archive":["Portico"],"relation":{},"ISSN":["0021-9304","1097-4636"],"issn-type":[{"value":"0021-9304","type":"print"},{"value":"1097-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,3]]}}}