{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:57:59Z","timestamp":1791928679200,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,9,13]],"date-time":"2004-09-13T00:00:00Z","timestamp":1095033600000},"content-version":"vor","delay-in-days":3543,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Mater. Res."],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A method of tissue digestion using sodium hydroxide was applied to the isolation and recovery of ultra\u2010high\u2010molecular\u2010weight polyethylene (UHMWPE) particles from tissues around failed total hip replacements. Density gradient ultracentrifugation of the digested tissues was performed to separate the UHMWPE from cell debris and other particulates. Fourier transform infrared spectroscopy and differential scanning calorimetry (DSC) verified that the recovered particles were UHMWPE. When viewed by scaning electron microscopy, individual particles were clearly observed and were either rounded or elongated. The majority were submicron in size. The application of this method to the study or particles from periprosthetic tissues may elucidate aspects of biomaterial particles size and shape that are important to the biologic response to, and clinical outcome of, total joint replacement. \u00a9 1995 John wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/jbm.820290118","type":"journal-article","created":{"date-parts":[[2005,5,27]],"date-time":"2005-05-27T19:39:18Z","timestamp":1117222758000},"page":"127-131","source":"Crossref","is-referenced-by-count":306,"title":["Isolation of predominantly submicron\u2010sized UHMWPE wear particles from periprosthetic tissues"],"prefix":"10.1002","volume":"29","author":[{"given":"P.","family":"Campbell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Yeom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"McKellop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. P.","family":"Schmalzried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. C.","family":"Amstutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,9,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/00003086-199203000-00003","article-title":"Mechanism and clinical significance of wear debris induced osteolysis","volume":"276","author":"Amstutz H. C.","year":"1992","journal-title":"Clin. Orthop."},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1302\/0301-620X.72B6.2246300","article-title":"Localized endosteal bone lysis in relation to the femoral components of cemented total hip arthroplasty","volume":"72","author":"Anthony P. P.","year":"1990","journal-title":"J. Bone Jt. Surg."},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2106\/00004623-198870020-00015","article-title":"A rat model of resorption of bone at the cemented interface in the presence of polyethylene","volume":"70","author":"Howie D. W.","year":"1989","journal-title":"J. Bone Jt. Surg."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199072020-00014"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199274060-00006"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1097\/00003086-198907000-00017","article-title":"A clinical\u2010pathological\u2010biochemical study of the membrane surrounding loosened and nonloosened total hip arthroplasties","volume":"244","author":"Goodman S. B.","year":"1989","journal-title":"Clin. Orthop."},{"key":"e_1_2_1_8_2","unstructured":"J.Emmanual R.Yapp andA.Hedley \u201cRecovery of biomaterial wear debris from membranes of failed joints for characterization \u201d presented at the Sixteenth Annual Meeting of the Society for Biomaterials Charleston North Carolina 1990."},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1302\/0301-620X.74B3.1587882","article-title":"Size of metallic and polyethylene debris particles in failed cemented total hip replacements","volume":"74","author":"Lee J. M.","year":"1992","journal-title":"J. Bone Jt. Surg."},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820280415"},{"key":"e_1_2_1_11_2","unstructured":"P.Campbell A.Nazarian andH. C.Amstutz \u201cSubmicron polyethylene wear debris is extensive in periprosthetic tissues \u201d presented at the Nineteenth Annual Meeting of the Society for Biomaterials Birmingham Alabama April 28\u2010May 2 1993."},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jab.770040202"},{"key":"e_1_2_1_13_2","first-page":"252","volume-title":"The Theory of Vibrational Spectroscopy and Its Application to Polymeric Materials","author":"Painter P. C.","year":"1982"},{"key":"e_1_2_1_14_2","unstructured":"H.McKellop P.Campbell S. H.Park T.Schmalzried H. C.Amstutz andA.Sarmiento \u201cOrigin of submicron UHMWPE wear debris in total hip arthroplasty \u201dClin. Orthop. in press."},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1302\/0301-620X.76B1.8300684","article-title":"Composition and morphology of wear debris in failed uncemented total hip replacement","volume":"76","author":"Shanbhag A. S.","year":"1994","journal-title":"J. Bone Jt. Surg."},{"key":"e_1_2_1_16_2","first-page":"161","article-title":"Letter to the editor","volume":"75","author":"Campbell P.","year":"1993","journal-title":"J. Bone Joint Surg."},{"key":"e_1_2_1_17_2","unstructured":"P.Campbell H.McKellop G.Belcher S.Ma andT. P.Schmalzried \u201cAutomated particle sizing following digestion of periprosthetic tissues: What are we measuring?\u201d presented at the Nineteenth Annual Meeting of the Society for Biomaterials Birmingham Alabama April 28\u2010May 2 (1993)."},{"key":"e_1_2_1_18_2","unstructured":"S.Haq P.Campbell A.Gelman andN.Kossovsky \u201cPhoton correlation spectroscopy of wear particles in periprosthetic tissues \u201d presented at the Nineteenth Annual Meeting of the Society for Biomaterials Birmingham Alabama April 28\u2010May 2 1993."},{"key":"e_1_2_1_19_2","unstructured":"W. J.Maloney L.Smith D.Huene andH.Rubash \u201cCharacterization of in vivo wear particles isolated from membranes around failed cementless total hip replacements \u201d presented at the Implant Retrieval Symposium of the Society for Biomaterials St. Charles Illinois Sept. 17\u201320 1992."},{"key":"e_1_2_1_20_2","unstructured":"J.Chiba W.Maloney M.Horikoshi L.McIntyre andH.Rubash \u201cBiochemical and morphological analyses of activated human macrophages and fibroblasts by human polyethylene particles \u201d presented at the Thirtyninth Annual Meeting of the Orthopaedic Research Society San Francisco California Feb. 15\u201318 1993."}],"container-title":["Journal of Biomedical Materials Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.820290118","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.820290118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T17:11:09Z","timestamp":1695834669000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.820290118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.1002\/jbm.820290118"],"URL":"https:\/\/doi.org\/10.1002\/jbm.820290118","archive":["Portico"],"relation":{},"ISSN":["0021-9304","1097-4636"],"issn-type":[{"value":"0021-9304","type":"print"},{"value":"1097-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1]]}}}