{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:53:57Z","timestamp":1787914437407,"version":"build-2784847793"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,9,13]],"date-time":"2004-09-13T00:00:00Z","timestamp":1095033600000},"content-version":"vor","delay-in-days":3512,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Mater. Res."],"published-print":{"date-parts":[[1995,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to evaluate the interface attachment strength and histology of hydroxylapatite (HA) coated and uncoated titanium and cobalt\u2013chromium alloy implants. The canine transcortical plug model was utilized. Four different hydroxylapatite coatings were evaluated. <jats:italic>In vitro<\/jats:italic> analysis confirmed that all coatings met FDA guidelines for HA coatings. An unspecified FDA parameter, porosity was found to range from 5\u201315%. Mechanical testing of the bone\u2013implant interface demonstrated large variation in the performance of the coatings. However, further evaluation of two of the coatings did not demonstrate variations in mechanical characteristics. The histologic findings confirmed the mechanical testing results. The coatings which demonstrated the best mechanical characteristics had excellent bone apposition and uniformity and maintenance of the HA coating at all time periods upon histologic evaluation. Conversely, the coatings which demonstrated inferior mechanical characteristics demonstrated variable amounts of bone apposition and moderate to severe coating degradation and breakup. Cell\u2010mediated osteolysis was observed in regions of severe coating degradation, and particle migration was noted in regions far from the interface. It was hoped that the four coatings would behave similarly as they all met current FDA guidelines. The only parameter which differed significantly among the coatings was coating porosity. Our results indicate that coatings with large porosities were associated with increased coating degradation and poor mechanical performance and osteolysis at the bone\u2013coating interface. \u00a9 1995 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/jbm.820290215","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T11:35:41Z","timestamp":1104492941000},"page":"239-245","source":"Crossref","is-referenced-by-count":99,"title":["<i>In vivo<\/i> mechanical and histological characteristics of HA\u2010coated implants vary with coating vendor"],"prefix":"10.1002","volume":"29","author":[{"given":"Jeanette E.","family":"Dalton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,9,13]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"39","article-title":"Hydroxyapatite\u2010coated total hip prostheses: Two\u2010year clinical and roentgenographic results of 100 cases","volume":"261","author":"Geesink R. 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D.","year":"1983","journal-title":"Orthopedics"},{"key":"e_1_2_1_16_2","volume-title":"Fundamentals of Biostatistics","author":"Rosner B.","year":"1990"}],"container-title":["Journal of Biomedical Materials Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.820290215","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.820290215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T22:11:41Z","timestamp":1698358301000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.820290215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,2]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,2]]}},"alternative-id":["10.1002\/jbm.820290215"],"URL":"https:\/\/doi.org\/10.1002\/jbm.820290215","archive":["Portico"],"relation":{},"ISSN":["0021-9304","1097-4636"],"issn-type":[{"value":"0021-9304","type":"print"},{"value":"1097-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,2]]}}}