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Four types of nerve guides, with internal diameters ranging from 1.12\u20131.23 mm and wall thicknesses ranging from 0.34\u20130.68, were tested for this purpose. We evaluated the biodegradation, foreign body reaction and nerve regeneration by light microscopy, after three different implantation times (1, 2, and 3 months). After 2 months, we observed that all types of nerve guides had changed from a transparent to an opaque and swollen state, and that they had lost their strength. The foreign body reaction was characterized by the presence of giant cells and fibroblasts surrounding the degrading nerve guide. From this pilot study, we conclude that nerve guide type 1, with an internal diameter of 1.23 mm and a wall thickness of 0.34 mm, can ensure nerve regeneration in the case of a 1\u2010cm gap in the sciatic nerve of the rat. Nerve guides types 3 and 4, with relatively small lumens, show nerve compression due to a more pronounced swelling of the degrading tube. \u00a9 1995 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/jbm.820290612","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T11:28:14Z","timestamp":1104492494000},"page":"757-766","source":"Crossref","is-referenced-by-count":124,"title":["Biological performance of a degradable poly(lactic acid\u2010\u03b5\u2010caprolactone) nerve guide: Influence of tube dimensions"],"prefix":"10.1002","volume":"29","author":[{"given":"W. F. A.","family":"Den Dunnen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Van Der Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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