{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:21:32Z","timestamp":1789618892339,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,9,29]],"date-time":"2003-09-29T00:00:00Z","timestamp":1064793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This article describes a 30\u2010mm regeneration of severed peripheral nerve axons along collagen filaments. Two thousand or 4000 31\u2010mm\u2010long collagen filaments were grafted to bridge a 30\u2010mm defect of the rat sciatic nerve. A collagen tube was grafted as a control. The mean number and mean fiber diameter of regenerated myelinated axons were 330 \u00b1 227 and 2.7 \u00b1 0.9 \u03bcm in the distal end of the 2000 collagen\u2010filaments nerve guide, and 564 \u00b1 275 and 2.5 \u00b1 1.1 \u03bcm in the distal end of the 4000 collagen\u2010filaments nerve guide at 12 weeks postoperatively, whereas in the distal end of the collagen tube, no regenerated axon was found. These results suggest that the collagen filaments guide axons of the rat's sciatic nerve to regenerate for 30 mm and act as a scaffold for axonal regeneration. Thirty\u2010millimeter nerve regeneration of a 1\u2010mm\u2010diameter rat sciatic nerve by an artificial nerve guarantees a clinical application of the implant which should be very important for patients and surgeons. \u00a9 2003 Wiley Periodicals, Inc. J Biomed Mater Res 67A: 467\u2013474, 2003<\/jats:p>","DOI":"10.1002\/jbm.a.10103","type":"journal-article","created":{"date-parts":[[2003,10,15]],"date-time":"2003-10-15T16:50:42Z","timestamp":1066236642000},"page":"467-474","source":"Crossref","is-referenced-by-count":67,"title":["Bridging a 30\u2010mm nerve defect using collagen filaments"],"prefix":"10.1002","volume":"67A","author":[{"given":"Satoru","family":"Yoshii","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Oka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Shima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ataru","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Akagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,9,29]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1997.tb01313.x"},{"key":"e_1_2_5_3_2","first-page":"1","article-title":"A collagen\u2010based nerve guide conduit for peripheral nerve repair: An electrophysiological study of nerve regeneration in rodents and nonhuman primates","volume":"307","author":"Archibald SJ","year":"1991","journal-title":"J Comp Neurol"},{"key":"e_1_2_5_4_2","first-page":"452","article-title":"Experimental peripheral nerve repair tubulation","volume":"15","author":"Braun RM","year":"1964","journal-title":"Surg Forum"},{"key":"e_1_2_5_5_2","first-page":"226","article-title":"Autogenous vein graft as a conduit for nerve regeneration","volume":"91","author":"Chiu DTW","year":"1982","journal-title":"Surgery"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345840630071601"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/02844318309013106"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198811000-00020"},{"key":"e_1_2_5_9_2","first-page":"606","article-title":"Ueber Neuroplastik auf dem Wege der Transplantation","volume":"25","author":"Gluck T","year":"1880","journal-title":"Arch Klin Chir"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(85)90162-1"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)91294-6"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1006750"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1964.21.9.0737"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/90.2.285"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490060302"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)91135-3"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091310403"},{"key":"e_1_2_5_18_2","first-page":"307","article-title":"Peripheral nerve repair with bioresorbable prosthesis","volume":"29","author":"Nyilas E","year":"1983","journal-title":"Trans Am Soc Artif Intern Organs"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0072-968X(78)80047-3"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1946.3.5.0375"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(84)90079-7"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198408000-00001"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(75)90379-6"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1054\/JHSB.1999.0074"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7111"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7095"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(76)90475-4"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)03025-0"},{"key":"e_1_2_5_29_2","first-page":"1315","volume-title":"Operative hand surgery","author":"Wilgis EFS","year":"1993"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(82)90215-1"},{"key":"e_1_2_5_31_2","first-page":"119","article-title":"La retine des vertebres","volume":"9","author":"Ramon y Cajal S","year":"1893","journal-title":"Cellule"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)91289-1"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(81)90095-X"},{"key":"e_1_2_5_34_2","first-page":"368","article-title":"Die Entwickelung der ersten Nervenbahnen beim menschlichen Embryo. Uebersichyliche Darstellung","author":"His W","year":"1887","journal-title":"Arch Anat Physiol Lpz"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90379-9"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(87)90064-1"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.a.10103","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.10103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T05:29:56Z","timestamp":1697174996000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.10103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9,29]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,11]]}},"alternative-id":["10.1002\/jbm.a.10103"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.10103","archive":["Portico"],"relation":{},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9,29]]}}}