{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:47:25Z","timestamp":1758905245938},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,11,4]],"date-time":"2003-11-04T00:00:00Z","timestamp":1067904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2003,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We synthesized positively charged biodegradable hydrogels with different poly(propylene fumarate\u2010<jats:italic>co<\/jats:italic>\u2010ethylene glycol) [P(PF\u2010<jats:italic>co<\/jats:italic>\u2010EG)] block copolymers and agmatine\u2010modified poly(ethylene glycol)\u2010tethered fumarate [Agm\u2010PEGF] by radical crosslinking and investigated the effect of copolymer composition and agmatine modification on their degradation. Hydrogels were incubated in phosphate\u2010buffered saline (PBS) at 37\u00b0C with periodic PBS changes. All hydrogels experienced a slight mass loss over 4 weeks, ranging from 10\u201320%. Hydrogels with a molar ratio of ethylene glycol repeating units to propylene fumarate repeating units (EG\/PF) of 9.3 degraded faster than hydrogels with an EG\/PF ratio of 0.6. Agmatine\u2010modified hydrogels degraded faster than unmodified hydrogels. The weight swelling ratio of the hydrogels at pH 7 increased over 4 weeks while increases in the EG\/PF ratio and agmatine modification showed greater swelling. After 2 weeks, degraded hydrogels swollen at pH 3 demonstrated significantly lower weight swelling ratios than at pH 5, 7, and 9. Our results suggest that the hydrophilicity of the P(PF\u2010<jats:italic>co<\/jats:italic>\u2010EG) copolymer and agmatine modification have a small effect on the degradation of P(PF\u2010<jats:italic>co<\/jats:italic>\u2010EG) hydrogels. \u00a9 2003 Wiley Periodicals, Inc. J Biomed Mater Res 67A: 1148\u20131154, 2003<\/jats:p>","DOI":"10.1002\/jbm.a.10147","type":"journal-article","created":{"date-parts":[[2003,11,7]],"date-time":"2003-11-07T11:01:25Z","timestamp":1068202885000},"page":"1148-1154","source":"Crossref","is-referenced-by-count":12,"title":["Effect of hydrophilicity and agmatine modification on degradation of poly(propylene fumarate\u2010<i>co<\/i>\u2010ethylene glycol) hydrogels"],"prefix":"10.1002","volume":"67A","author":[{"given":"Kazuhiro","family":"Tanahashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonios G.","family":"Mikos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,11,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)50210-1"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1163\/156856292X00169"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199603)30:3<295::AID-JBM4>3.0.CO;2-L"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(91)90031-5"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820280408"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(87)90001-9"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9797(85)90010-4"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/bm0200433"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.10077"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704153"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201x.2000.00646.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb09343.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199811)42:2<312::AID-JBM17>3.0.CO;2-K"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1163\/156856202753525963"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/ma970312v"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(96)85755-3"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(02)00170-9"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/la981027n"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0032-3861(95)91204-K"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.a.10147","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.10147","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm.a.10147","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.10147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T08:40:28Z","timestamp":1693903228000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.10147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11,4]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,12,15]]}},"alternative-id":["10.1002\/jbm.a.10147"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.10147","archive":["Portico"],"relation":{},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,11,4]]}}}