{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:30:45Z","timestamp":1791117045363,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,3,6]],"date-time":"2003-03-06T00:00:00Z","timestamp":1046908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In order to reduce the compliance mismatch between the native artery and the artificial graft, we have developed a coaxial double\u2010tubular compliant graft, using multiply micropored segmented polyurethane (SPU) thin films, which mimics the relationship between the intraluminal pressure and vessel internal diameter (P\u2010D) of the native artery (termed \u201cJ\u201d curve). The graft was coaxially assembled by inserting a high\u2010compliance inner tube with a heparin\u2010immobilized photocured gelatin coating layer into a low\u2010compliance outer tube with a photocured hydrophilic polymer coating layer. Twenty\u2010eight coaxial double\u2010tubular compliant grafts were implanted into the canine common carotid arteries in an end\u2010to\u2010end fashion for up to 12 months. The overall patency rate was 86% (24\/28), and neither rupture nor aneurysmal formation was observed. A neoarterial wall was formed via transanastomotic and transmural tissue ingrowth, resulting in neoarterial tissue formation on the luminal surface and into the intertubular space of the double\u2010tubular graft, accompanied by mainly myofibroblasts and inflammatory cells in the early stage and endothelialization and collagen\u2010rich extracellular matrices in the late stage of implantation. Surrounding\u2010tissue adhesion with the outer tube was prevented by the hydrophilic polymer coating. Although the J curve of the implanted prototype model was preserved 1 month after implantation, the impaired J curves were observed because of tissue ingrowth and tissue adhesion between the outer surface of the inner tube and the surrounding tissues 3 and 6 months after implantation. At 12 months after implantation, however, the implanted coaxial double\u2010tubular graft exhibited high compliance due to biodegradation of the SPU films. \u00a9 2003 Wiley Periodicals, Inc. J Biomed Mater Res 65A: 170\u2013181, 2003<\/jats:p>","DOI":"10.1002\/jbm.a.10462","type":"journal-article","created":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T21:01:35Z","timestamp":1051822895000},"page":"170-181","source":"Crossref","is-referenced-by-count":27,"title":["Coaxial double\u2010tubular compliant arterial graft prosthesis: Time\u2010dependent morphogenesis and compliance changes after 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