{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T20:41:44Z","timestamp":1769200904219,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,6,10]],"date-time":"2003-06-10T00:00:00Z","timestamp":1055203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The sheep seems to be a promising model of osteoporosis and biomaterial osteointegration in osteopenic bone. The long\u2010term ovariectomized sheep model was used for the biological investigation of bone healing around uncoated and hydroxyapatite (HA)\u2010coated pedicle screws in osteopenic bone. Four sheep were ovariectomized and four sheep were sham\u2010operated. Twenty\u2010four months after surgery, the animals were implanted with uncoated and HA\u2010coated stainless steel screws in the lumbar vertebral pedicles. Four months later, bone\u2010to\u2010implant contact, bone ingrowth, and bone hardness were measured around screws. Uncoated stainless steel presented significantly (<jats:italic>p<\/jats:italic> &lt; 0.0005) lower bone\u2010to\u2010implant contact in healthy and osteopenic bone compared with HA\u2010coated stainless steel. HA significantly improved bone ingrowth in healthy bone (<jats:italic>p<\/jats:italic> &lt; 0.05) compared with uncoated stainless steel. Osteopenia significantly (<jats:italic>p<\/jats:italic> &lt; 0.05) reduced the area of bone ingrowth around the screw threads for both types of implants. In the inner thread area, bone microhardness significantly increased (<jats:italic>p<\/jats:italic> &lt; 0.05) in HA\u2010coated surface versus uncoated for healthy and osteopenic bone. HA coating significantly enhances bone\u2010to\u2010implant contact also in osteopenic bone in comparison with uncoated stainless steel surfaces. Bone ingrowth and mineralization are ameliorated by the osteoconductive HA coating. However, osteopenia seems to greatly influence bone ingrowth processes around the implanted screws regardless of the characteristics of the material surface. \u00a9 2003 Wiley Periodicals, Inc. J Biomed Mater Res 66A: 176\u2013183, 2003<\/jats:p>","DOI":"10.1002\/jbm.a.10605","type":"journal-article","created":{"date-parts":[[2003,6,24]],"date-time":"2003-06-24T10:15:25Z","timestamp":1056449725000},"page":"176-183","source":"Crossref","is-referenced-by-count":48,"title":["Biological assessment of the bone\u2013screw interface after insertion of uncoated and hydroxyapatite\u2010coated pedicular screws in the osteopenic sheep"],"prefix":"10.1002","volume":"66A","author":[{"given":"M.","family":"Fini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Giavaresi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Greggi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Martini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. 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