{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:11:38Z","timestamp":1761675098339},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,7,22]],"date-time":"2004-07-22T00:00:00Z","timestamp":1090454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2004,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>HADgels are newly developed photocrosslinked hyaluronate hydrogels. They are produced from an aqueous solution of a hyaluronan derivative (HAD) in which cinnamic acid is introduced into the carboxyl moiety of hyaluronan using 3\u2010aminopropanol as a spacer. High\u2010energy ultraviolet irradiation of the HAD solution induces photodimerization of cinnamic acid, resulting in the development of a macromolecular network of each hyaluronan to water\u2010insoluble hydrogels. The biocompatibility and biodegradation of HADgels were evaluated by guinea pig intracutaneous injection testing for up to 28 days. By macroscopic and histological observations, HADgels showed good tissue compatibility and did not induce excess inflammation at the injection sites. Biodegradation of the HADgels clearly depended on the degree of crosslinking at the fixed weight concentrations of HAD (0.5% and 1.0%). In addition, serum analyses showed that the injected guinea pigs did not produce specific antibodies against HADgels. These results indicate that HADgels have preferable biocompatibility and can be used as a new class of injectable, absorbable biomaterial, especially for preventing postsurgical adhesion formations. \u00a9 2004 Wiley Periodicals, Inc. 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Cinnamic acid derivatives. US patent 6 107 410.2000."},{"key":"e_1_2_5_17_2","unstructured":"MiyamotoK KurahashiY KanoH. Photocurable hyaluronic acid and process for producing same and photocured crosslinked\u2010hyaluronic acid derivative and medical material using the same. US patent 6 602 859.2003."},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00403a039"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(62)90095-7"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70241-X"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/01926230390204360"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(77)90149-1"},{"key":"e_1_2_5_23_2","unstructured":"Premarket notification of HADgel\u2122; 510(K) summary of safety and effectiveness. Center for Devices and Radiological Health. US Food and Drug Administration.2001. 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