{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T09:26:55Z","timestamp":1773221215436,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,5,17]],"date-time":"2005-05-17T00:00:00Z","timestamp":1116288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2005,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A subretinal drug delivery system was developed to overcome the limitations of current treatments for retinal disease. A rod\u2010shaped implant was made by embedding the corticosteroid triamcinolone acetonide within a biodegradable polycaprolactone polymer matrix. The implant was fabricated by homogenously mixing the polymer and drug in solvent. The mixture was then dried, melted, and extruded, and the prepared solid form was drawn into a filament. The rods were mechanically sectioned to a length of 2 mm with a diameter of up to 320 \u03bcm. The rods were successfully implanted into the subretinal space of six rabbits. No complications were observed during the 4\u2010week follow\u2010up period. Initial observations of the implantation and elution characteristics revealed that polycaprolactone is well tolerated by the retinal tissue and that the implant can elute steroid for a period of at least 4 weeks without eliciting inflammatory response or complications. <jats:italic>In vitro<\/jats:italic> drug elution rates of different polymer to drug ratios and geometries into a balanced salt solution\/bovine serum albumin (1%) solution showed an early rapid\u2010release phase and late first\u2010order phase. Histology and device retrieval after implantation revealed minimal encapsulation and good preservation of cellular morphology during the follow\u2010up period and a more fibrous polymer microstructure of the implant. \u00a9 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2005<\/jats:p>","DOI":"10.1002\/jbm.a.30294","type":"journal-article","created":{"date-parts":[[2005,5,17]],"date-time":"2005-05-17T15:46:38Z","timestamp":1116344798000},"page":"437-444","source":"Crossref","is-referenced-by-count":39,"title":["Fabrication, implantation, elution, and retrieval of a steroid\u2010loaded polycaprolactone subretinal implant"],"prefix":"10.1002","volume":"73A","author":[{"given":"Nathan R. F.","family":"Beeley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana V.","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo A. 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