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The behavior of CoCr pellets immersed in human serum, fetal bovine serum (FBS), synovial fluid, and water were studied using time\u2010of\u2010flight secondary ion mass spectroscopy (ToF\u2010SIMS). The differences in the corrosive nature of human serum, FBS, synovial fluid, and water after 5 days immersion were highlighted by the oxide\/hydroxide layer, which was, respectively, 25, 10, 1.5, and 3\u20133.5 nm thick. The thickness of calcium phosphate deposit from human serum, FBS, and synovial fluid was, respectively, 30, 20, and 2 nm. Co and Cr ions migrated from the bulk metal surface and were trapped in the serum deposits, where chromium existed as oxides, hydroxides, and phosphates, whereas the cobalt chemistry was dominated only by phosphates and hydroxides. This may account for the composition of wear debris from CoCr orthopedic implants, which are predominantly hydroxyphosphate compounds. From the literature, proteoglycans, pyrophosphates, phospholipids, lubricin, and superficial zone protein (SZP) have been identified as possible causes for the insignificant deposit of calcium phosphate from synovial fluid. Circulation of these compounds around the whole implant may inhibit calcium phosphate deposition and therefore contribute to osteolysis. \u00a9 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2005<\/jats:p>","DOI":"10.1002\/jbm.a.30430","type":"journal-article","created":{"date-parts":[[2005,8,8]],"date-time":"2005-08-08T18:17:32Z","timestamp":1123525052000},"page":"365-373","source":"Crossref","is-referenced-by-count":34,"title":["The effects of calcium phosphate deposition upon corrosion of CoCr alloys and the potential for implant failure"],"prefix":"10.1002","volume":"75A","author":[{"given":"A. C.","family":"Lewis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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