{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:24:28Z","timestamp":1791177868716,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2006,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hyaluronic acid (HA) is a naturally occurring polysaccharide with unique biomedical applications. We have studied the cohesive and rheological properties of HA of three molecular weights (0.35 \u00d7 10<jats:sup>6<\/jats:sup> \u20131.80 \u00d7 10<jats:sup>6<\/jats:sup> Da) and found that the cohesive nature of HA was highly dependent on molecular weight and solution concentration. To a first approximation, the cohesive nature of HA in solution correlates with concentration, independent of molecular weight. Several rheological parameters correlated with molecular weight: zero shear viscosity, complex viscosity, and the complex viscosity at the crossover point. The cohesive properties of the HA solutions, measured by dynamic aspiration (Poyer et al, J Cataract Refract Surg 1998;24:1130\u20131135), were found to decrease as the zero shear viscosity increases. The cohesive properties of HA polymer in solution were found to correlate with the high frequency complex viscosity and high frequency loss modulus independent of molecular weight. \u00a9 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2006<\/jats:p>","DOI":"10.1002\/jbm.a.30623","type":"journal-article","created":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T18:18:16Z","timestamp":1133201896000},"page":"721-728","source":"Crossref","is-referenced-by-count":83,"title":["Rheological and cohesive properties of hyaluronic acid"],"prefix":"10.1002","volume":"76A","author":[{"given":"Samuel J.","family":"Falcone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Palmeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr941199z"},{"key":"e_1_2_5_3_2","first-page":"151","article-title":"Viscoelastic agents","volume":"15","author":"Larson RS","year":"1989","journal-title":"CLAO J"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199447030-00009"},{"issue":"2","key":"e_1_2_5_5_2","first-page":"15","article-title":"Intra\u2010articular hyaluronans in knee osteoarthritis: Rationale and practical considerations","volume":"33","author":"Kelly MA","year":"2004","journal-title":"Am J Orthop"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.1968.360060603"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/bm010170j"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0282(20011005)59:4<191::AID-BIP1018>3.0.CO;2-M"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/bm0055798"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016488709102834"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(98)80109-0"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0141-8130(00)00136-7"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(02)00050-5"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.44.12.817"},{"issue":"5","key":"e_1_2_5_15_2","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3233\/BIR-1993-305-612","article-title":"Comparisons of the oscillatory shear viscoelasticity and composition of pathological synovial fluids","volume":"30","author":"Gomez JE","year":"1993","journal-title":"Biorheology"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200006)43:6<1192::AID-ANR2>3.0.CO;2-L"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.23.3115"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.a.30623","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.30623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T06:06:01Z","timestamp":1697090761000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.30623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,28]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,3,15]]}},"alternative-id":["10.1002\/jbm.a.30623"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.30623","archive":["Portico"],"relation":{},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,28]]}}}