{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:23:38Z","timestamp":1790886218007,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,5,5]],"date-time":"2006-05-05T00:00:00Z","timestamp":1146787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Biocompatibility of cell\u2010enclosing capsules, defined as suppression of pericapsular cellular reactions, is one of the factors governing the success of enclosed cell transplantation in <jats:italic>in vivo<\/jats:italic> cell therapy. Agarose capsules of subsieve size, less than 100 \u03bcm in diameter, and conventional size, \u223c300\u20131000 \u03bcm in diameter, were implanted into the peritoneal cavity and epididymal fat pads of mice and rats, respectively, to determine the effect of a reduction in diameter to subsieve size. The degree of cellular reaction to the subsieve\u2010size capsules was much lower than that of the conventional\u2010size microcapsules, independent of implantation site. The frequency of overgrown subsieve\u2010size capsules retrieved from the peritoneal cavities was less than 5% in contrast to \u223c20% for capsules 387 \u03bcm in diameter. In addition, no increase in floating cells, which are generated through capsule stimulation, was observed in the peritoneal cavity only with subsieve\u2010size capsules. From these results, we concluded that subsieve\u2010size capsules are more biocompatible than microcapsules of conventional size. \u00a9 2006 Wiley Periodicals, Inc. 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